Molecular Mechanisms of Basal Cell and Squamous Cell Carcinomas

1. Front Matter

   Pages i-xv

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2. The Epidemiology of Basal Cell and Squamous Cell Carcinoma

   • Hao Wang, Thomas L. Diepgen

   Pages 1-9

3. Histology of Epithelial Skin Tumors

   • Jörg Reichrath, Kerstin Querings

   Pages 10-17

4. UV Damage and DNA Repair in Basal Cell and Squamous Cell Carcinomas

   • Knuth Rass

   Pages 18-30

5. Papillomavirus Infections and Cancerogenesis of Squamous Cell and Basal Cell Carcinomas

   • Guido Bens

   Pages 31-42

6. The Immune System and Nonmelanoma Skin Cancers

   • Elma D. Baron

   Pages 43-48

7. Cytogenetics of Basal Cell Carcinoma and Squamous Cell Carcinomas

   • Melanie A. Carless, Kevin J. Ashton, Lyn R. Griffiths

   Pages 49-57

8. The Hedgehog Signaling Pathway and Epithelial Skin Cancer

   • Julia Reifenberger

   Pages 58-65

9. p53 Protein and Nonmelanoma Skin Cancer

   • Vladislava O. Melnikova, Honnavara N. Ananthaswamy

   Pages 66-79

10. TGF-β Pathway and Cancerogenesis of Epithelial Skin Tumors

    • Miguel Quintanilla, Eduardo Pérez-Gómez, Diana Romero, Mar Pons, Jaime Renart

    Pages 80-93

11. PDGF Pathways and Growth of Basal Cell and Squamous Cell Carcinomas

    • Jingwu Xie

    Pages 94-107

12. Apoptosis and Cancerogenesis of Basal Cell and Squamous Cell Carcinoma

    • Peter Erb, Jingmin Ji, Marion Wernli, Stanislaw A. Büchner

    Pages 108-114

13. The Role of Telomerase for Cancerogenesis of Basal Cell and Squamous Cell Carcinomas

    • Eva-Maria Fabricius

    Pages 115-133

14. Back Matter

    Pages 135-137

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apid progress in the understanding of carcinogenesis and pathology of epitheUal skin cancer has led to new strategies for the prevention Rand treatment of these malignancies. The goal of this volume is to comprehensively cover in a highly readable overview our present knowledge of pathogenetic mechanisms and molecular biology of Basal Cell and Squamous Cell Carcinomas. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in epidemiology, histology, photobiology, immunology, cytogenetics, and molecular pathol­ ogy to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of this book to summarize essential up-to-date information for clinicians and scientists interested in the biology of Basal Cell and Squamous Cell Carcinomas. The chapters are written by authors who are experts in their respective research areas, and I am gratefixl for their willingness to contribute to this book. I would also like to express my thanks to Ron Landes, Cynthia Conomos, Sara Lord and all the other members of the Landes Bioscience staff for their expertise, diligence and patience in helping me complete this work. Jorg Reichrathy Prof, Dn med. CHAPTER 1 The Epidemiology of Basal Cell and Squamous Cell Carcinoma Hao Wang and Thomas L.

• DNA
• apoptosis
• cancer
• carcinogenesis
• carcinoma
• cell
• cytogenetics
• genetics
• histology
• immunology
• infection
• molecular pathology
• pathology
• skin
• tumor

• Clinic for Dermatology, Allergology and Venerology, The Saarland University Hospital, Homburg/Saar, Germany

  Jörg Reichrath

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