Overview
- Features the latest information on I Domain Integrins
- Features the latest information on these transmembrane receptors
- Will be a valuable source of information for academic, as well as biotech and pharma researchers
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 819)
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Table of contents (11 chapters)
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Front Matter
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Back Matter
Keywords
About this book
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version.
I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition.
Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book.
In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling.
New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Editors and Affiliations
Bibliographic Information
Book Title: I Domain Integrins
Editors: Donald Gullberg
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-94-017-9153-3
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2014
Hardcover ISBN: 978-94-017-9152-6Published: 30 July 2014
Softcover ISBN: 978-94-024-0290-2Published: 17 September 2016
eBook ISBN: 978-94-017-9153-3Published: 14 July 2014
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XIV, 179
Number of Illustrations: 18 b/w illustrations, 32 illustrations in colour
Topics: Biomedicine general, Life Sciences, general, Gene Function, Medical Biochemistry