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This is the first book of its kind to offer an advanced understanding of the latest technologies in stem cell expansion and manufacturing
This is a book designed specifically to provide powerful research opportunities for those interested in perusing work in large scale production of stem cells for clinical application
This book is specially formatted so that it is not only a source on stem cell biology and therapeutic application but also a good foundation for understanding basic regenerative medicine
This book is a valuable reference resource for both experienced investigators in stem cell therapy as well as those in cell culture, bioengineering, tissue engineering and developmental biology fields
With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.
Use of Human Embryonic Stem Cells in Therapy.- Human Neural Stem Cell-based Cell- and Gene-therapy for Neurological Diseases.- Vascular Stem Cell Therapy.- Bioprocessing of Human Pluripotent Stem Cells for Cell Therapy Applications.- Blood Cell Bioprocessing: The Haematopoietic System and Current Status of In-vitro Production of Red Blood Cells.- Bioprocessing Challenges Associated with the Purification of Cellular Therapies.- Separation Technologies for Stem Cell Bioprocessing.