Structure and Physics of Viruses

1. Front Matter

   Pages i-xix

   PDF

2. The Viral Machine

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction: The Structural Basis of Virus Function

      • Mauricio G. Mateu

      Pages 3-51

   3. The Basic Architecture of Viruses

      • José R. Castón, José L. Carrascosa

      Pages 53-75

3. Determination of the Structure and Physical Properties of Viruses

   1. Front Matter

      Pages 77-77

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   2. Conventional Electron Microscopy, Cryo-Electron Microscopy and Cryo-Electron Tomography of Viruses

      • José R. Castón

      Pages 79-115

   3. X-Ray Crystallography of Viruses

      • Nuria Verdaguer, Damià Garriga, Ignacio Fita

      Pages 117-144

   4. Nuclear Magnetic Resonance Spectroscopy to Study Virus Structure

      • José L. Neira

      Pages 145-176

   5. Fluorescence, Circular Dichroism and Mass Spectrometry as Tools to Study Virus Structure

      • José L. Neira

      Pages 177-202

   6. Combined Approaches to Study Virus Structures

      • Daniel Badia-Martinez, Hanna M. Oksanen, David I. Stuart, Nicola G. A. Abrescia

      Pages 203-246

   7. Atomic Force Microscopy of Viruses

      • Pedro J. de Pablo

      Pages 247-271

   8. Optical Tweezers to Study Viruses

      • J. Ricardo Arias-Gonzalez

      Pages 273-304

4. Structural Foundations of Virus Properties and Functions

   1. Front Matter

      Pages 305-305

      PDF

   2. Assembly of Simple Icosahedral Viruses

      • José M. Almendral

      Pages 307-328

   3. Structure and Assembly of Complex Viruses

      • Carmen San Martín

      Pages 329-360

   4. Nucleic Acid Packaging in Viruses

      • Ana Cuervo, María I. Daudén, José L. Carrascosa

      Pages 361-394

   5. Virus Maturation

      • Laura R. Delgui, José F. Rodríguez

      Pages 395-415

   6. Virus Morphogenesis in the Cell: Methods and Observations

      • Cristina Risco, Isabel Fernández de Castro

      Pages 417-440

   7. Virus-Receptor Interactions and Receptor-Mediated Virus Entry into Host Cells

      • José M. Casasnovas

      Pages 441-466

   8. Entry of Enveloped Viruses into Host Cells: Membrane Fusion

      • Vicente Más, José A. Melero

      Pages 467-487

This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.

• Applications
• Function
• Physics
• Structure
• Virus
• Protein Structure

• "Severo Ochoa" (CSIC_UAM), And Dept. of Molecular Biology, Centro de Biología Molecular, Madrid, Spain

  Mauricio G. Mateu

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