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The book is a unique compilation of review articles which comprehensively describe tetraspanin evolution, structure and their function at the molecular level
The book discusses a diverse range of biological phenomena and cellular functions that involve tetraspanin proteins
The book is well supported by the illustrative material to help the readers to follow the flow of information
Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection. The book summarises recent advances in the fields of biology in which the role of tetraspanins have been established and also covers the molecular evolution of the tetraspanin superfamily and structural aspects of the organisation of tetraspanin microdomains.
Foreword Chapter 1 Structural Bases for Tetraspanin Functions. Michel Seigneuret, Hélène Conjeaud, Hui-Tang Zhang and Xiang-Peng Kong Chapter 2 The Evolution of Tetraspanins Through a Phylogenetic Lens. Rob DeSalle, Tung-Tien Sun, Tjard Bergmann and Antonio Garcia-España Chapter 3 Organisation of the Tetraspanin Web. Eric Rubinstein, Stéphanie Charrin and Michael G. Tomlinson Chapter 4 Dynamic Partitioning of Tetraspanins Within Plasma Membranes. Olga Barreiro, Francisco Sanchez-Madrid, Cédric Espenel and Pierre-Emmanuel Milhiet Chapter 5 Tetraspanins as Regulators of Protein Trafficking. Elena Odintsova and Fedor Berditchevski Chapter 6 The Role of Tetraspanins in Cell Migration and Intercellular Adhesion. Emilio Tejera, Mónica Sala-Valdés, Vera Rocha-Perugini and María Yáñez Mó Chapter 7 Genetic Evidence for Tetraspanin Functions. Martin E. Hemler Chapter 8 Tetraspanins in Lower Eukaryotes. Hiroki Moribe and Eisuke Mekada Chapter 9 The Role of Tetraspanin Complexes in Egg-Sperm Fusion. Virginie Barraud-Lange and Claude Boucheix Chapter 10 Tetraspanins and Immunity. Mark D. Wright and Shoshana Levy Chapter 11 Tetraspanins in Cancer. Leonie K. Ashman and Margot Zöller Chapter 12 Uroplakins as Unique Tetraspanin Networks. Tung-Tien Sun, Gert Kreibich, Angel Pellicer, Xiang-Peng Kong and Xue-Ru Wu Chapter 13 Essential Tetraspanin Functions in the Vertebrate Retina. Andrew F.X. Goldberg Chapter 14 The Role of CD81 in HCV and Plasmodium Infection. Laurence Cocquerel and Olivier Silvie Chapter 15 Tetraspanins as Facilitators of Viral and Cellular Information Transfer. Markus Thali Index