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Biomedical Sciences | Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

Mandel, Silvia (Ed.)

2013, XVII, 396 p. 39 illus., 32 illus. in color.

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  • Unique concept of the book in terms of predictive diagnostics, targeted preventive measures and individualised algorithms for treatment of neurodegenerative diseases
  • Very useful information for professionals
  • Unlimited audience

The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments.

This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.

Content Level » Research

Keywords » Neurodegenerative diseases - Neuropsychiatric diseases - Personalized treatment - Predictive diagnosis - Preventive measures

Related subjects » Biomedical Sciences - Neurology - Neuroscience - Public Health

Table of contents 

Part I

1. What is this book series about? Foreword of Book Series Editor; O. Golubnitschaja

2. Preface; S. Mandel

3.     Introductory chapter; S. Mandel and O. Golubnitschaja

Part II

4. Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of “down-stream” pathologies as cost-effective personalised medicine; K. Yeghiazaryan, J. Flammer, O. Golubnitschaja

5. Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders; S. Fulda and M. Manconi

6. New animal models of progressive neurodegeneration:  tools for developing predictive diagnostics and identifying presymptomatic therapeutic targets; A. L. Marriott, D. A. Gill, C. A. Shaw, R. A. Tasker

7. Tau pathology: A selected view on the current status; I. Gozes

Part III

8. The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases; S. A. Mandel & A. D. Korczyn

9. Making clinical trials of Alzheimer’s disease delay-of-onset a reality by use of a prognostic genetic biomarker; Iris Grossman

10. An update on CSF biomarkers of Parkinson’s disease; Peter LeWitt, B Russell Huber, Jing Zhang

Part IV

11. Glaucomatous optic neuropathy: Risk assessment and potential targets for effective prevention and treatments tailored to the patient; O. Golubnitschaja, K. Yeghiazaryan, J. Flammer

Part V

12. Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies; B. Nefussy & V. E. Drory

13. Recent advances in ALS research: perspectives for personalized clinical application; C. Benkler, D. Offen, E. Melamed, T. Amit, S. Mandel, M. B.H. Youdim, O. Weinreb

Part VI

14. Exercise in Multiple Sclerosis – an Integral Component of Disease Management; A. Döring, C. F. Pfueller, F. Pau, J. Dörr

15. Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegenerative Diseases; A. Shabo (Shvo) & M. Scarpa

Part VII

16. Personalized Medicine In Rare Paediatric Neurometabolic Diseases; R. Tomanin, C. M. Bellettato, F. D’Avanzo, A. Zanetti, A. Ceci, D. Begley, M. Scarpa

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