Logo - springer
Slogan - springer

Biomedical Sciences | Cilia and Nervous System Development and Function

Cilia and Nervous System Development and Function

Tucker, Kerry L., Caspary, Tamara (Eds.)

2013, XIII, 277 p. 69 illus., 38 illus. in color.

Available Formats:

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.


(net) price for USA

ISBN 978-94-007-5808-7

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase

learn more about Springer eBooks

add to marked items


Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.


(net) price for USA

ISBN 978-94-007-5807-0

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days

add to marked items

  • Only book to combine the explosive field of ciliary biology with a focus on the emergent roles of cilia for the central and peripheral nervous systems
  • All chapters written by researchers personally involved in cutting-edge advancements in the respective field
  • Comprehensive analysis of the multitude of roles played by the primary cilium in neurogenesis and neural function
Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and  process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Content Level » Research

Keywords » Brain function - Cilia - Obesity - Sonic hedgehog - Wnt signaling

Related subjects » Biomedical Sciences - Cancer Research - Evolutionary & Developmental Biology - Human Physiology - Neuroscience

Table of contents 


1 Primary and motile cilia: their ultrastructure and ciliogenesis

2 Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord       Development

3 Primary cilia and brain development

4 Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-Neuronal Cells

5 Primary Cilia and Inner Ear Sensory Epithelia

6 Neuronal Cilia and Obesity

7 Motile cilia and brain function: ependymal motile cilia development, organization, function and their associated pathologies

8 Primary Cilia and Brain Cancer

9 Abnormalities of the Central Nervous System across the Ciliopathy Spectrum

Popular Content within this publication 



Read this Book on Springerlink

New Book Alert

Get alerted on new Springer publications in the subject area of Biomedicine (general).