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Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

  • Book
  • © 2012

Overview

Editors:
  1. J. Robin Harris

    1. Inst. of Zoology, University of Mainz, Mainz, Germany

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  • This book is unique in that it contains both Basic Science and Clinical consideration of the amyloid diseases
  • Up-to-date knowledge is presented by authoritative researchers and clinicians
  • The broad range of techniques used to study amyloidogenesis is clear from the topics included in the book
  • Some emphasis appears relating the cytotoxicity of protein oligomers as well as fibrils in the genesis of amyloid disease
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Subcellular Biochemistry (SCBI, volume 65)

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Table of contents (22 chapters)

  1. Front Matter

    Pages 1-1
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Introduction and Technical Survey: Protein Aggregation and Fibrillogenesis

      • J. Robin Harris, Nathaniel G. N. Milton
      Pages 3-25

  3. Basic Science

    1. Front Matter

      Pages 27-27
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    2. Fibril Formation by Short Synthetic Peptides

      • Andrew Smith
      Pages 29-51

    3. In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides

      • NĂşria Benseny-Cases, Oksana Klementieva, Josep Cladera
      Pages 53-74

    4. Tau Fibrillogenesis

      • Nitin Chaudhary, Ramakrishnan Nagaraj
      Pages 75-90

    5. Prion Protein Aggregation and FibrillogenesisIn Vitro

      • Jan Stöhr
      Pages 91-108

    6. α-Synuclein Aggregation and Modulating Factors

      • Katerina E. Paleologou, Omar M. A. El-Agnaf
      Pages 109-164

    7. Pathological Self-Aggregation ofb2-Microglobulin: A Challenge for Protein Biophysics

      • Gennaro Esposito, Alessandra Corazza, Vittorio Bellotti
      Pages 165-183

    8. Islet Amyloid Polypeptide: Aggregation and Fibrillogenesisin vitroand Its Inhibition

      • Janine Seeliger, Roland Winter
      Pages 185-209

    9. Mechanisms of Transthyretin Aggregation and Toxicity

      • Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar, David H. Small
      Pages 211-224

    10. Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins

      • Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev, Sorin Luca
      Pages 225-251

    11. Aggregation and Fibrillogenesis of Proteins not Associated with Disease: A Few Case Studies

      • Moritz LassĂ©, Juliet A. Gerrard, F. Grant Pearce
      Pages 253-270

    12. Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs

      • Alagiri Srinivasan
      Pages 271-294

    13. Experimental Inhibition of Fibrillogenesis and Neurotoxicity by amyloid-beta (Aβ) and Other Disease-Related Peptides/Proteins by Plant Extracts and Herbal Compounds

      • Suresh Kumar, Edward J. Okello, J. Robin Harris
      Pages 295-326

  4. Clinical Science: The Cerebral and Systemic Amyloid Diseases

    1. Front Matter

      Pages 327-327
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    2. Alzheimer’s Disease

      • Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza
      Pages 329-352

    3. Modeling the Polyglutamine Aggregation Pathway in Huntington’s Disease: From Basic Studies to Clinical Applications

      • Keizo Sugaya
      Pages 353-388

    4. Parkinson’s Disease

      • Timothy R. Mhyre, James T. Boyd, Robert W. Hamill, Kathleen A. Maguire-Zeiss
      Pages 389-455
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Keywords

About this book

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Editors and Affiliations

  • Inst. of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

Bibliographic Information

  • Book Title: Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

  • Editors: J. Robin Harris

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-94-007-5416-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2012

  • Hardcover ISBN: 978-94-007-5415-7Published: 06 December 2012

  • Softcover ISBN: 978-94-007-9736-9Published: 29 January 2015

  • eBook ISBN: 978-94-007-5416-4Published: 09 December 2012

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XVIII, 650

  • Topics: Biomedicine general, Entomology, Medicine/Public Health, general

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