2012, XVII, 648 p. 114 illus., 41 illus. in color.
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This book is unique in that it contains both Basic Science and Clinical consideration of the amyloid diseases
Up-to-date knowledge is presented by authoritative researchers and clinicians
The broad range of techniques used to study amyloidogenesis is clear from the topics included in the book
Some emphasis appears relating the cytotoxicity of protein oligomers as well as fibrils in the genesis of amyloid disease
This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.