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Biomedical Sciences | Reprogramming Microbial Metabolic Pathways

Reprogramming Microbial Metabolic Pathways

Series: Subcellular Biochemistry, Vol. 64

Wang, Xiaoyuan, Chen, Jian, Quinn, Peter (Eds.)

2012, XIV, 442 p.

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  • Methods for reprogramming industrial microorganisms
  • Methods to increase production of valuable biochemicals by fermentation
  • Information on metabolic engineering of different microorganisms

Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.

Content Level » Research

Keywords » Fermentation - Industrial microbes - Metabolic engineering - Microbial Metabolic pathways - Reprogramming microorganisms

Related subjects » Biomedical Sciences - Biotechnology - Microbiology

Table of contents 


Part I: Emerging Methods for Redesigning Microorganisms

1. Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators; Roee Amit
2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways; Cong T. Trinh and R. Adam Thompson
3. Evolutionary Engineering for Industrial Microbiology; Niti Vanee, Adam B. Fisher and Stephen S. Fong
4. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches; Joshua T. Ellis, Ronald C. Sims and Charles D. Miller
5. Synthetic Biology Triggers New Era of Antibiotics Development; Jianfeng Wang, Zhi-Qiang Xiong, Hailin Meng, Yiguang Wang and Yong Wang
6. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis; Juan F. Martín and Paloma Liras
7. Systems Analysis of Microbial Adaptations to Simultaneous Stresses; Ross P. Carlson, Olusegun J. Oshota and Reed L. Taffs
8. Metabolic Reprogramming under Microaerobic and Anaerobic Conditions in Bacteria; Yue Shan, Yong Lai and Aixin Yan
9. Tunable Promoters in Synthetic and Systems Biology; Tore Dehli, Christian Solem and Peter Ruhdal Jensen10. Analysis of Corynebacterium glutamicum Promoters and Their Applications; Jan Nešvera, Jiří Holátko and Miroslav Pátek

Part II: Metabolic Engineering for Overproducing Chemicals and Materials

11. Production of Fumaric Acid by Fermentation; Adrie J.J. Straathof and Walter M. van Gulik
12. Metabolic Engineering of Microorganisms for Vitamin C Production; Jingwen Zhou, Guocheng Du and Jian Chen
13. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum; Takashi Hirasawa, Jongpill Kim, Tomokazu Shirai, Chikara Furusawa and Hiroshi Shimizu
14. Microbial Metabolic Engineering for L-threonine Production; Xunyan Dong, Peter J. Quinn and Xiaoyuan Wang
15. The Production of Coenzyme Q10 in Microorganisms; Corinne P. Cluis, Dominic Pinel and Vincent J. Martin
16. Genetic Modification and Bioprocess Optimization for S-adenosyl-L-methionine biosynthesis; Xiaoqing Hu, Peter J. Quinn, Zhou Wang, Guoqiang Han and Xiaoyuan Wang
17. Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-based Products; Christopher J. Brigham, Natalia Zhila, Ekaterina Shishatskaya, Tatiana G. Volova and Anthony J. Sinskey
18. Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei; Bernhard Seiboth, Silvia Herold and Christian P. Kubicek
19. Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis; Andreas Aurich, Robert Specht, Roland A. Müller, Ulrich Stottmeister, Venelina Yovkova, Christina Otto, Martina Holz, Gerold Barth, Philipp Heretsch, Franziska A. Thomas, Dieter Sicker and Athanassios Giannis 




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