Overview
- Editors:
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MARCO FALASCA
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CTR DIABETES BARTS, Queen Mary University of London, UK, LONDON E1 2AT, United Kingdom
- A comprehensive overview of the current state of research and where the field of research is progressing to
- A useful tool for understanding how inositol signaling is used to target complex human diseases
- Increase our understanding of the role of inositol signaling in protein regulation
- Includes supplementary material: sn.pub/extras
- Includes supplementary material: sn.pub/extras
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Table of contents (12 chapters)
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- Alessandra Ghigo, Alessia Perino, Emilio Hirsch
Pages 43-60
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- Dave Bridges, Alan R. Saltiel
Pages 61-85
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- Peter J. Wen, Shona L. Osborne, Frederic A. Meunier
Pages 87-98
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- Banafshé Larijani, Dominic L. Poccia
Pages 99-110
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- François Vergez, Christian Recher, Bernard Payrastre
Pages 163-184
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- Leonela Amoasii, Karim Hnia, Jocelyn Laporte
Pages 209-233
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- Sara Mongiorgi, Matilde Y. Follo, Cristina Clissa, Roberto Giardino, Milena Fini, Lucia Manzoli et al.
Pages 235-245
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- Sandra Hakim, Micka C. Bertucci, Sarah E. Conduit, David L. Vuong, Christina A. Mitchell
Pages 247-314
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Back Matter
Pages 315-318
About this book
Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLCpathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
Editors and Affiliations
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CTR DIABETES BARTS, Queen Mary University of London, UK, LONDON E1 2AT, United Kingdom
MARCO FALASCA