Logo - springer
Slogan - springer

Biomedical Sciences | GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

Series: Subcellular Biochemistry, Vol. 63

Dupré, Denis J., Hébert, Terence E., Jockers, Ralf (Eds.)

2012, VIII, 300 p.

Available Formats:
eBook
Information

Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.

You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.

After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.

 
$159.00

(net) price for USA

ISBN 978-94-007-4765-4

digitally watermarked, no DRM

Included Format: PDF and EPUB

download immediately after purchase


learn more about Springer eBooks

add to marked items

Hardcover
Information

Hardcover version

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$199.00

(net) price for USA

ISBN 978-94-007-4764-7

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

Softcover
Information

Softcover (also known as softback) version.

You can pay for Springer Books with Visa, Mastercard, American Express or Paypal.

Standard shipping is free of charge for individual customers.

 
$199.00

(net) price for USA

ISBN 978-94-017-8099-5

free shipping for individuals worldwide

usually dispatched within 3 to 5 business days


add to marked items

  • This is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes
  • Several colors images
  • Compilations of manuscripts made from experts in the field

This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally?  Therefore, the topics to be covered in this book are:

1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis;
2) Assembly of signalling complexes, or subunits of the complex and their organization;
3) GPCR oligomerization;
4) GPCR trafficking;
5) Problems of trafficking: pharmacological chaperones to the rescue.

Content Level » Research

Keywords » Assembly - Chaperone - G protein coupled receptor - Signaling - Trafficking

Related subjects » Biomedical Sciences - Internal Medicine - Pharmacology & Toxicology

Table of contents 

1. ER-bound steps in the biosynthesis of G protein-coupled receptors; Christian Nanoff and Michael Freissmuth 

2. Role of chaperones in G protein coupled receptor signalling complex assembly; Denis J. Dupré, Maha M. Hammad, Patrick Holland and Jaime Wertman

3. GPCR oligomerization: contribution to receptor biogenesis: Kathleen Van Craenenbroeck

4. The functional size of GPCRs- monomers, dimers or tetramers?; Darlaine Pétrin and Terence E. Hébert

5. Regulation of post-Golgi traffic of G protein-coupled receptors; Guangyu Wu

 6. Regulated GPCR trafficking to the plasma membrane: general issues and the CCR5 chemokine receptor example; Hamasseh Shirvani, Gabriel Gätà and Stefano Marullo

7. Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors; Deborah L. Segaloff

8. Chaperone-mediated assembly of G protein complexes; Barry M. Willardson and Christopher M. Tracy 

9. Synthesis and assembly of G protein bg dimers: comparison of in vitro and in vivo studies; Jane Dingus and John D. Hildebrandt 

10. Preferential assembly of G-abg complexes directed by the g subunits; Janet D. Robishaw

11. G Protein Trafficking; Philip B. Wedegaertner 

12. Differential assembly of GPCR signaling complexes determines signaling specificity; Pascal Maurice , Abla Benleulmi-Chaachoua & Ralf Jockers 

 13. GPCR and voltage-gated calcium channels (VGCC) signaling complexes; Christophe Altier 

14. Pharmacological chaperones correct misfolded GPCRs and rescue function: trafficking as a therapeutic target; Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick, P. Michael Conn

Popular Content within this publication 

 

Articles

Read this Book on Springerlink

Services for this book

New Book Alert

Get alerted on new Springer publications in the subject area of Biomedicine (general).