Macario, Alberto J.L., Conway de Macario, Everly, Francesco, Cappello
2013, XVI, 116 p. 26 illus., 23 illus. in color.
Springer eBooks may be purchased by end-customers only and are sold without copy protection (DRM free). Instead, all eBooks include personalized watermarks. This means you can read the Springer eBooks across numerous devices such as Laptops, eReaders, and tablets.
You can pay for Springer eBooks with Visa, Mastercard, American Express or Paypal.
After the purchase you can directly download the eBook file or read it online in our Springer eBook Reader. Furthermore your eBook will be stored in your MySpringer account. So you can always re-download your eBooks.
A unique and comprehensive survey and description of diseases, the chaperonopathies, in which molecular chaperones are etiologic-pathogenic factors
An easy-to-grasp, well-illustrated with tables and figures, panoramic view of the state-of-the-art analysis of chaperonopathies
Unveils new routes to diagnose chaperonopathies, establish prognosis, treat and manage patients properly, thereby showing the path for future research
Memory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer.
1. Introduction: What is this book about?; What the clinician and the pathologist must know about chaperonopathies; What the general public must know about chaperonopathies.- 2. Stress and anti-stress mechanisms.- 3. The chaperoning system.- 4. Location and function of chaperones.- 5. The chaperonopathies.- 6. Molecular features of chaperonopathies.- 7. Hsp-chaperone subpopulations and their chaperonopathies.- 8. Structural and hereditary chaperonopathies.- 9. Chaperonopathies and genetic polymorphisms: a. Chap eronopathies due to gene dysregulation; b. Chaperonopathies of the aged; c. Chaperonopathies by mistake; d. Chaperonopathies in disease pathogenesis.- 10. Chaperones as biomarkers.- 11. Chaperonotherapy.- 12. Conclusion.- Bibliography