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Innovation in Vaccinology

from design, through to delivery and testing

  • Book
  • © 2012

Overview

Editors:
  1. Selene Baschieri

    1. Italian National Agency for New Technolo, Energy and Sustainable Economic Developm, ENEA, Rome, Italy

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  • Updated focus on emerging technologies in the field of vaccinology
  • Snap-shots on all the different steps of vaccine development
  • Multidisciplinarity

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Vaccine Design

    1. Front Matter

      Pages 1-1
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  3. Vaccine design

    1. Design of New Vaccines in the Genomic and Post-genomic Era

      • Laura Serino, Kate L. Seib, Mariagrazia Pizza
      Pages 3-15

    2. Comparing In Silico Results to In Vivo and Ex Vivo of Influenza-Specific Immune Responses After Vaccination or Infection in Humans

      • Filippo Castiglione, Benjamin Ribba, Olivier Brass
      Pages 17-42

  4. Vaccine Delivery

    1. Front Matter

      Pages 43-43
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  5. Vaccine delivery

    1. Virus Glycoproteins Tagged with the Human Fc Domain as Second Generation Vaccine Candidates

      • Silvia Loureiro, Elena Robinson, Hongying Chen, Pongsathon Phapugrangkul, Camilo Colaco, Ian M Jones
      Pages 45-63

    2. Engineered Viruses as Vaccine Platforms

      • Antonella Folgori, Stefania Capone
      Pages 65-86

    3. Virus-Like Particles as Efficient Delivery Platform to Induce a Potent Immune Response

      • Fabien Rebeaud, Martin Bachmann
      Pages 87-122

    4. Filamentous Bacteriophages: An Antigen and Gene Delivery System

      • Rossella Sartorius, Domenico Russo, Luciana D’Apice, Piergiuseppe De Berardinis
      Pages 123-134

    5. Liposomes and Other Nanoparticles as Cancer Vaccines and Immunotherapeutics

      • Joseph G. Altin
      Pages 135-178

    6. Plant-Based Vaccine Delivery Strategies

      • Chiara Lico, Carla Marusic, Floriana Capuano, Giampaolo Buriani, Eugenio Benvenuto, Selene Baschieri
      Pages 179-203

    7. TLR Agonists as Vaccine Adjuvants

      • Mark A. Tomai, John P. Vasilakos
      Pages 205-228

    8. Mucosal Vaccines for Enteric Bacterial Pathogens

      • Paolo Pasquali
      Pages 229-248

  6. Pre-clinical Vaccine Testing

    1. Front Matter

      Pages 249-249
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  7. Pre-clinical vaccine testing

    1. The Importance of Animal Models in the Development of Vaccines

      • Tadele G. Kiros, Benoît Levast, Gaël Auray, Stacy Strom, Jill van Kessel, Volker Gerdts
      Pages 251-264

    2. Correlates of Vaccine-Induced Immunity: Historical Perspectives and Future Challenges

      • Ian J. Amanna
      Pages 265-285

  8. Back Matter

    Pages 287-288
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Keywords

About this book

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.

Editors and Affiliations

  • Italian National Agency for New Technolo, Energy and Sustainable Economic Developm, ENEA, Rome, Italy

    Selene Baschieri

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