Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Endoplasmic Reticulum Stress in Health and Disease

  • Book
  • © 2012

Overview

Editors:
  1. Patrizia Agostinis

    1. Dept Molec Cell Bio, K.U. Leuven, B-3000 Leuven, Belgium

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Samali Afshin

    1. School of Natural Science, Department of Biochemistry, NUI Galway, Galway, Ireland

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive cover of the latest developments in ER stress
  • Up to date and succinct description of the role of ER stress in pathophysiology
  • Novel aspects of ER stress physiology never discussed before
  • Includes supplementary material: sn.pub/extras

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages 1-1
    Download chapter PDF

  2. Cellular Responses to ER Stress

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Biology of the Endoplasmic Reticulum

      • Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali
      Pages 3-22

    3. A Tight-Knit Group: Protein Glycosylation, Endoplasmic Reticulum Stress and the Unfolded Protein Response

      • Jared Q Gerlach, Shashank Sharma, Kirk J Leister, Lokesh Joshi
      Pages 23-39

    4. ER Stress Signaling Pathways in Cell Survival and Death

      • Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis
      Pages 41-73

    5. Endoplasmic Reticulum-mitochondria connections, calcium cross-talk and cell fate: a closer inspection

      • Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo, Cristina Fasolato
      Pages 75-106

    6. ER Stress and UPR Through Dysregulated ER Ca2+ Homeostasis and Signaling

      • Tim Vervliet, Santeri Kiviluoto, Geert Bultynck
      Pages 107-142

    7. Regulation of ER Stress Responses by microRNAs

      • Danielle E. Read, Ananya Gupta, Karen Cawley, Sanjeev Gupta
      Pages 143-161

    8. ER Stress As Modulator of Autophagy Pathways

      • María Salazar, Sonia Hernández-Tiedra, Mar Lorente, Guillermo Velasco
      Pages 163-184

    9. Physiological ER Stress: The Model of Insulin-Secreting Pancreatic b-Cells

      • Mohammed Bensellam, Patrick Gilon, Jean-Christophe Jonas
      Pages 185-211

  3. ER stress in physiological & pathological conditions

    1. Front Matter

      Pages 205-205
      Download chapter PDF

    2. Pathological ER Stress in β Cells

      • Fumihiko Urano, Bryan O’Sullivan-Murphy
      Pages 215-230

    3. Endoplasmic Reticulum Stress and the Unfolded Protein Response in Lipid Metabolism and Obesity

      • Sana Basseri, Richard C. Austin
      Pages 231-256

    4. ER Stress and Inflammation

      • Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko, Peter Vandenabeele
      Pages 257-279

    5. ER Stress in Intestinal Inflammatory Disease

      • Michal F. Tomczak, Arthur Kaser, Richard S. Blumberg
      Pages 281-298

    6. Role of ER Stress in Dysfunction of the Nervous System

      • Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano
      Pages 299-321

    7. Endoplasmic Reticulum (ER) Stress in Amyotrophic Lateral Sclerosis (ALS)

      • Han-Jou Chen, Jackie de Belleroche
      Pages 323-337

    8. Cardiovascular Disease and Endoplasmic Reticulum Stress

      • Jody Groenendyk, Marek Michalak
      Pages 339-355

    9. Signaling the Unfolded Protein Response in cancer

      • Stéphanie Lhomond, Eric Chevet
      Pages 357-382

    10. UPR Activation in Cancer Cells: A Double-Edged Sword

      • Ethel R. Pereira, Amanda M. Preston, Linda M. Hendershot
      Pages 383-412
Back to top

Keywords

About this book

The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.

Editors and Affiliations

  • Dept Molec Cell Bio, K.U. Leuven, B-3000 Leuven, Belgium

    Patrizia Agostinis

  • School of Natural Science, Department of Biochemistry, NUI Galway, Galway, Ireland

    Samali Afshin

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation