A Structural Perspective on Respiratory Complex I

1. Front Matter

   Pages i-x

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2. Structure and Mechanism of Complex I

   1. Front Matter

      Pages 1-1

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3. Structure and mechanism of complex I

   1. Structure of Complex I

      • Rouslan G. Efremov, Leonid Sazanov

      Pages 3-21

   2. On the Mechanism of the Respiratory Complex I

      • Thorsten Friedrich, Petra Hellwig, Oliver Einsle

      Pages 23-59

   3. Iron–Sulfur Clusters in Complex I

      • Eiko Nakamaru-Ogiso

      Pages 61-79

   4. Current Topics of the Inhibitors of Mitochondrial Complex I

      • Hideto Miyoshi

      Pages 81-98

   5. My Fifty Years Association with Complex I Study

      • Tomoko Ohnishi

      Pages 99-105

4. Evolution of Complex I

   1. Front Matter

      Pages 107-107

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5. Evolution of complex I

   1. The Evolutionary Relationship Between Complex I and [NiFe]-Hydrogenase

      • Anne Volbeda, Juan C. Fontecilla-Camps

      Pages 109-121

   2. Recruitment of the Antiporter Module – A Key Event in Complex I Evolution

      • Vamsi Krishna Moparthi, Cecilia Hägerhäll

      Pages 123-143

6. Mutations in Complex I Subunits and Medical Implications

   1. Front Matter

      Pages 145-145

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7. Mutations in complex I subunits and medical implications

   1. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach

      • Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, Akemi Matsuno-Yagi

      Pages 147-169

   2. Cellular Consequences of mtDNA-Encoded Mutations in NADH:Ubiquinone Oxidoreductase

      • Mina Pellegrini, Jan A. M. Smeitink, Peter H. G. M. Willems, Werner J. H. Koopman

      Pages 171-189

8. Subunit Composition and Assembly of Mitochondrial Complex I

   1. Front Matter

      Pages 191-191

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9. Subunit composition and assembly of mitochondrial complex I

   1. The Assembly of Human Complex I

      • Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans

      Pages 193-217

   2. Complexes I in the Green Lineage

      • Claire Remacle, Patrice Hamel, Véronique Larosa, Nitya Subrahmanian, Pierre Cardol

      Pages 219-244

10. Supercomplexes in Mitochondria

    1. Front Matter

       Pages 245-245

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11. Supercomplexes in mitochondria

    1. Supramolecular Organization of the Respiratory Chain

       • Janet Vonck

       Pages 247-277

12. Back Matter

    Pages 279-286

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The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.

• NADH:ubiquinone oxidoreductase (complex I)
• bioenergetics
• electron transfer and proton translocation
• membrane protein structure
• respiratory chain
• Protein Structure

• , Mitochondrial Biology Unit, Medical Research Council, Cambridge, United Kingdom

  Leonid Sazanov

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