Overview
- Editors:
-
-
Tamas Balla
-
, NICHD, National Institutes of Health, Bethesda, USA
-
Matthias Wymann
-
, Cancer- and Immunobiology, University of Basel, Basel, Switzerland
-
John D. York
-
, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA
- In depth discussion of the state of the art of phosphoinositide research
- Experts in the field discussing the 'hot' topics in phosphoinositide research
- A volume dedicated to the enzymes involved in the synthesis and degradation of phosphoinositides
- Includes supplementary material: sn.pub/extras
Access this book
Other ways to access
Table of contents (9 chapters)
-
-
- Shane Minogue, Mark G. Waugh
Pages 1-24
-
- Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan, Richard Anderson
Pages 25-59
-
- Aurelie Gresset, John Sondek, T. Kendall Harden
Pages 61-94
-
-
-
- Alessandra Ghigo, Fulvio Morello, Alessia Perino, Emilio Hirsch
Pages 183-213
-
- Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic, Christina A. Mitchell
Pages 215-279
-
- Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal, Clare G. Fedele, Christina A. Mitchell, Nicholas R. Leslie
Pages 281-336
-
- Tamas Balla, Matthias Wymann, John D. York
Pages 337-337
-
Back Matter
Pages 334-334
About this book
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Editors and Affiliations
-
, NICHD, National Institutes of Health, Bethesda, USA
Tamas Balla
-
, Cancer- and Immunobiology, University of Basel, Basel, Switzerland
Matthias Wymann
-
, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, USA
John D. York