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Biomedical Sciences | Stem Cells and Human Diseases

Stem Cells and Human Diseases

Srivastava, Rakesh K., Shankar, Sharmila (Eds.)

2012, X, 630 p.

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  • Mechanisms by which stem cell regulate regulate cellular function and normal organ development
  • Mechanisms by which cancer stem cells regulate cancer initiation and progression
  • Role of cancer stem cells in drug resistance
  • Signaling pathways regulating self-renewal capacity of normal stem cells and cancer stem cells
  • Development of novel drugs to target cancer stem cells
  • Role of microRNA and genes in stem cells and cancer stem cells
  • Genetic and proteomic profiling in stem cells

There have been major advances in understanding the behavior of stem cells and their roles in tissue regeneration, homeostasis and therapy.  Cancer stem cell hypothesis opened a new opportunity for treating and preventing cancers by targeting cancer stem cells or cancer initiating cells.  An increased understanding of stem cell behavior and biology along with rapid advancement of high throughput screening has led to the discovery and development of novel drugs that control stem cell self-renewal and differentiation.  In near future, these molecules will be very useful for treating and preventing several human diseases. 

While progress on the clinical front has been slower than desired, the use of stem cells for tissue regeneration and disease management has great potential in human health.

The first decade of the 21st century has brought with it significant progress in our understanding of stem cell or progenitor cells and their role in tissue regeneration and management of human diseases including cancer, neurodegenerative disorders, and heart diseases.  This book covers the current state-of-the-art knowledge on the role of stem cells in tissue regeneration, homeostasis and disease management.


  • Coverage of the biology of stem cell and their role in tissue regeneration and organogenesis.
  • Mechanism-based strategies for stem cell self-renewal and differentiation.
  • Role of cancer stem cells or tumor initiating cells in cancer initiation, progression, relapse and drug resistance.
  • Use of stem cells in treating several human diseases, such as Alzheimer’s disease, Parkinson’s disease, cancer and diabetes.

Content Level » Research

Keywords » Cancer Stem Cells - Drug Resistance - Physiology and Metabolisms - Stem Cells - microRNA

Related subjects » Biomedical Sciences - Entomology - Medicine

Table of contents 

  1. Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications; Brahma N. Singh, Sharmila Shankar and Rakesh K. Srivastava
  2. The Perspectives of Stem Cell-based Therapy in Neurological Diseases; Wojciech Maksymowicz, Joanna Wojtkiewicz, Hanna Kozłowska, Aleksandra Habich and Wlodek Lopaczynski
  3. Stem Cell-based Therapy for Lysosomal Storage Diseases; Brittni A. Scruggs, Xiujuan Zhang, Jeffrey M. Gimble and Bruce A. Bunnell
  4. Drosophila germline stem cells; Yalan Xing and Willis X. Li
  5. Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation; Peiman Hematti, Jaehyup Kim and Minoo Battiwalla
  6. Cancer Stem Cells in Solid Tumors, Markers and Therapy; Ortiz-Sánchez Elizabeth, González-Montoya José Luis, Langley Elizabeth and García-Carrancá Alejandro
  7. Cancer Stem Cells: Paradigm Shifting or Perishing Concept?; Senthil K Pazhanisamy and Keith Syson Chan†
  8. Genomics of Prostate Cancer; Kern Rei Chng, Shin Chet Chuah, Edwin Cheung
  9. Ischemia, reactive radicals, redox signaling and hematopoietic stem cells; Suman Kanji, Vincent J. Pompili and Hiranmoy Das
  10. Cancer stem cell models and role in drug discovery; Rohit Duggal, Boris Minev, Angelo Vescovi and Aladar Szalay
  11. Origins of Metastasis-Initiating Cells; Sara M. Nolte and Sheila K. Singh
  12. The Reduction of Callus Formation during Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells; Claudia Keibl and Martijn van Griensven
  13. Stem cells and leukemia; Vincenzo Giambra and Christopher R. Jenkins
  14. The role of adult bone marrow derived mesenchymal stem cells, growth factors and scaffolds in the repair of cartilage and bone; Antal Salamon and Erzsébet Toldy
  15. Worth the Weight: Adipose Stem Cells in Human Disease; Saleh Heneidi and Gregorio Chazenbalk
  16. Neural crest and Hirschsprung’s disease; Kim Hei-Man CHOW , Paul Kwong-Hang TAM, Elly Sau-Wai NGAN
  17. Common denominators of self-renewal and malignancy IN neural stem cells and GLIOMA; Grzegorz Wicher, Karin Holmqvist and Karin Forsberg-Nilsson
  18. Stem-like cells from brain tumours or vice versa?; Sara G.M. Piccirillo
  19. Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics; Rajneesh Pathania, Vadivel Ganapathy and Muthusamy Thangaraju
  20. Breast Cancer Stem Cells; Shane R. Stecklein and Roy A. Jensen
  21.  Translin/TRAX deficiency affects mesenchymal differentiation programs and induces bone marrow failure; Reiko Ishida, Katsunori Aoki, Kazuhiko Nakahara, Yuko Fukuda, Momoko Ohhori, Yumi Saito, Kimihiko Kano, Junichiro Matsuda, Shigetaka Asano, Richard T. Maziarz and Masataka Kasai
  22. Cancer therapies and Stem cells; Hiromichi Kimura
  23. Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas; Shi-Long Lu
  24. The Biology of Lung Cancer Stem Cells; Sandeep Singh and Srikumar P. Chellappan
  25. Stem Cell Characters in Primary and Metastatic Tumour Establishment; Maria Tsekrekou, Dimitris Mavroudis, Dimitris Kafetzopoulos, Despoina Vassou
  26. Plasticity of Cancer Stem Cells; Zhizhong Li
  27. Cross talks among Notch, Wnt, and Hedgehog signaling pathways regulate stem cell characteristics; Su-Ni Tang, Sharmila Shankar, and Rakesh K. Srivastava
  28. Global OMICs profiling and functional analysis of CD44+/CD24- stem-like cells in normal human breast tissue and breast cancer; Marina Bessarabova, Kornelia Polyak, Yuri Nikolsky
  29. Breast Cancer Stem Cells: Isolation, characterization and targeting; Anurag N. Paranjape

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