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Biomedical Sciences | Bacterial Adhesion - Chemistry, Biology and Physics

Bacterial Adhesion

Chemistry, Biology and Physics

Linke, Dirk, Goldman, Adrian (Eds.)

2011, XIV, 374 p.

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  • Includes methods from such diverse fields as microbiology, structural biology, biophysics and biochemistry
  • Has additional color figures in the online (PDF) version
  • Displays the principles of bacterial adhesion over a broad range of medically relevant species
  • Provides a broad overview of adhesion from multiple perspectives, ranging from biophysics to medical applications
  • Useful for clinical researchers who want to gain a broad understanding of the science behind nosocomial infections

Adhesion plays a major role in the bacterial lifestyle. Bacteria can adhere to organic and inorganic surfaces, to each other, and of course to host cells during pathogenesis.

The focus of this book is: how are such adhesion phenomena best studied? Microbial genetics experiments have greatly enhanced our knowledge of what bacterial factors are involved in adhesion. For numerous reasons, though, biochemical and structural biology knowledge of the molecular interactions involved in adhesion are limited. One major problem has been a lack of interdisciplinary research and understanding in the field. On the one hand, the microbiologists lack detailed knowledge of the biophysical possibilities and have limited access to the frequently expensive instrumentation involved while on the other hand, the experts in these methods frequently do not have access to the biological materials, nor do they necessarily understand the biological questions to be answered. The purpose of this book is thus to overcome this gap in communication between researchers in biology, chemistry and physics and to display the many ways and means to investigate bacterial adhesion. We hope to stimulate new and ground-breaking research.

Content Level » Research

Keywords » Bacterial Adhesion - Biophysics - Infectious Disease - Microbiology - Structural Biology

Related subjects » Biomedical Sciences - Biophysics & Biological Physics - Medical Microbiology - Microbiology

Table of contents 

Introduction; D. Linke and A. Goldman

1.    Adhesins of human pathogens from the genus Yersinia; J.C. Leo and M. Skurnik

2.    Adhesive mechanisms of Salmonella enteric; C. Wagner and M. Hensel

3.    Adhesion Mechanisms of Borrelia burgdorferi; S. Antonara, L. Ristow and J. Coburn

4.    Adhesins of Bartonella spp.; F. O´Rourke, T. Schmidgen, P.O. Kaiser, D. Linke and V.A.J. Kempf

5.    Adhesion Mechanisms of Plant-Pathogenic Xanthomonadeae; N. Mhedbi-Hajri, M.-A. Jacques and R. Koebnik

6.    Adhesion by Pathogenic Corynebacteria; E.A. Rogers, A. Das and H. Ton-That

7.    Adhesion Mechanisms of Staphylococci; C. Heilmann

8.    Protein Folding in Bacterial Adhesion: Secretion and Folding of Classical Monomeric Autotransporters; P. van Ulsen

9.    Structure and Biology of Trimeric Autotransporter Adhesins; A. Łyskowski, J.C. Leo and A. Goldman

10.  Crystallography and EM of chaperone/usher pilus systems; S. Geibel and G. Waksman

11.  Crystallography of Gram-positive Bacterial Adhesins; V. Krishnan and S.V.L. Narayana

12.  The nonideal coiled coil of M protein and its multifarious functions in pathogenesis; P. Ghosh

13.  Bacterial Extracellular Polysaccharides; K. Bazaka, R.J. Crawford, E.L. Nazarenko and E.P. Ivanova

14.  Carbohydrate mediated bacterial adhesion; R. J. Pieters

15.  The Application of NMR Techniques to Bacterial Adhesins; F. Shewmaker

16.  Electron microscopy techniques to study bacterial adhesion; I. Grin, H. Schwarz and D. Linke

17.  EM Reconstruction of Adhesins: Future Prospects; F. Ilaria and F. Giusti

18.  Atomic force microscopy to study intermolecular forces and bonds associated with bacteria; S.K. Lower

19.  Assessing Bacterial Adhesion on an Individual Adhesin and Single Pili Level using Optical Tweezers; O. Axner, M. Andersson, O. Björnham, M. Castelain, J. Klinth, E. Koutris and S. Schedin

20.  Short time-scale bacterial adhesion dynamics; J. Geng and N. Henry

21.  Deciphering Biofilm Structure and Reactivity by Multiscale Time-resolved Fluorescence Analysis; A. Bridier, E. Tischenko, F. Dubois-Brissonnet, J.-M. Herry, V. Thomas, S. Daddi-Oubekka, F. Waharte, K. Steenkeste, M.-P. Fontaine-Aupart and R. Briandet

22.  Inhibition of Bacterial Adhesion on Medical Devices; L.R. Rodrigues


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