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Cell Signaling Reactions

Single-Molecular Kinetic Analysis

  • Book
  • © 2011

Overview

Editors:
  1. Yasushi Sako

    1. , Cellular Informatics Laboratory, RIKEN, Wako, Japan

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  2. Masahiro Ueda

    1. Graduate School of Frontier Biosciences, Laboratories of Nanobiology, Osaka University, Suita, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • This would be the first book focusing on single-molecule “kinetics”
  • This book covers wide field of cell signaling processes currently studied in single-molecules
  • Theories, methods of data processing, and new technologies of single-molecule kinetics are described
  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-x
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  2. Single-Molecule Kinetic Analysis of Receptor Protein Tyrosine Kinases

    • Michio Hiroshima, Yasushi Sako
    Pages 1-32

  3. Single-Molecule Kinetic Analysis of Stochastic Signal Transduction Mediated by G-Protein Coupled Chemoattractant Receptors

    • Yukihiro Miyanaga, Masahiro Ueda
    Pages 33-57

  4. Single-Molecule Analysis of Molecular Recognition Between Signaling Proteins RAS and RAF

    • Kayo Hibino, Yasushi Sako
    Pages 59-78

  5. Single-Channel Structure-Function Dynamics: The Gating of Potassium Channels

    • Shigetoshi Oiki
    Pages 79-105

  6. Immobilizing Channel Molecules in Artificial Lipid Bilayers for Simultaneous Electrical and Optical Single Channel Recordings

    • Toru Ide, Minako Hirano, Takehiko Ichikawa
    Pages 107-120

  7. Single-Protein Dynamics and the Regulation of the Plasma-Membrane Ca2+ Pump

    • Carey K. Johnson, Mangala R. Liyanage, Kenneth D. Osborn, Asma Zaidi
    Pages 121-151

  8. Single-Molecule Analysis of Cell-Virus Binding Interactions

    • Terrence M. Dobrowsky, Denis Wirtz
    Pages 153-166

  9. Visualization of the COPII Vesicle Formation Process Reconstituted on a Microscope

    • Kazuhito V. Tabata, Ken Sato, Toru Ide, Hiroyuki Noji
    Pages 167-182

  10. In Vivo Single-Molecule Microscopy Using the Zebrafish Model System

    • Marcel J. M. Schaaf, Thomas S. Schmidt
    Pages 183-197

  11. Analysis of Large-Amplitude Conformational Transition Dynamics in Proteins at the Single-Molecule Level

    • Haw Yang
    Pages 199-219

  12. Extracting the Underlying Unique Reaction Scheme from a Single-Molecule Time Series

    • Chun Biu Li, Tamiki Komatsuzaki
    Pages 221-263

  13. Statistical Analysis of Lateral Diffusion and Reaction Kinetics of Single Molecules on the Membranes of Living Cells

    • Satomi Matsuoka
    Pages 265-296

  14. Noisy Signal Transduction in Cellular Systems

    • Tatsuo Shibata
    Pages 297-324

  15. Back Matter

    Pages 325-330
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About this book

This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.

Editors and Affiliations

  • , Cellular Informatics Laboratory, RIKEN, Wako, Japan

    Yasushi Sako

  • Graduate School of Frontier Biosciences, Laboratories of Nanobiology, Osaka University, Suita, Japan

    Masahiro Ueda

Bibliographic Information

  • Book Title: Cell Signaling Reactions

  • Book Subtitle: Single-Molecular Kinetic Analysis

  • Editors: Yasushi Sako, Masahiro Ueda

  • DOI: https://doi.org/10.1007/978-90-481-9864-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2011

  • Hardcover ISBN: 978-90-481-9863-4Published: 11 November 2010

  • Softcover ISBN: 978-94-007-9446-7Published: 26 November 2014

  • eBook ISBN: 978-90-481-9864-1Published: 04 November 2010

  • Edition Number: 1

  • Number of Pages: X, 330

  • Topics: Biomedicine general, Cell Biology, Biochemistry, general

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