Editors:
- Provides a comprehensive and detailed overview
- Edited and authored by experts with diverse backgrounds
- Includes an extensive bibliography
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Table of contents (20 chapters)
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Front Matter
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Histamine Biology and Physiology
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Front Matter
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Enzymology in Histamine Biology
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Front Matter
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Pharmacology of Histamine Noble Receptors and Their Ligands in Drug Development
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Front Matter
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Histamine Role in Immune Modulation and Regulation
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Front Matter
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Histamine in Regulation of Cell Proliferation and Differentiation
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Front Matter
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Histamine Role in Pathogenesis and Diagnosis of Allergic, Inflammatory, Autoimmune and Cancer Diseases
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Front Matter
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Histamine Role in Inflammation and Allergy
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Front Matter
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About this book
Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas.
This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.
Editors and Affiliations
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School of Medicine, Dept. Internal Medicine, Southern Illinois University, Springfield, USA
Nancy Khardori
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J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, India
Rahat Ali Khan
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Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, India
Trivendra Tripathi
Bibliographic Information
Book Title: Biomedical Aspects of Histamine
Book Subtitle: Current Perspectives
Editors: Nancy Khardori, Rahat Ali Khan, Trivendra Tripathi
DOI: https://doi.org/10.1007/978-90-481-9349-3
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media B.V. 2011
Hardcover ISBN: 978-90-481-9348-6Published: 11 October 2010
Softcover ISBN: 978-94-017-8499-3Published: 14 October 2014
eBook ISBN: 978-90-481-9349-3Published: 30 September 2010
Edition Number: 1
Number of Pages: XXXV, 441
Topics: Biomedicine general