Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.
1 Role of HSF1 in Infectious Disease, Iswar S. Singh, Nirav G. Shah, Eid Almutairy and Jeffrey D. Hasday; 2 Propagating Prions: An Essential Role for Molecular Chaperones, Emma Guinan, Alice Blumlein, Sarah A. Cusack, Ciara Moran, Harriët M. Loovers and Gary W. Jones; 3 Role of Heat Shock Proteins in Viral Infection, M. Gabriella Santoro, Carla Amici and Antonio Rossi; 4 Chaperones in the Morphogenesis of Viruses, Matthias P. Mayer; 5 Role of Host Molecular Chaperones in Responses to Bacterial Infection and Endotoxin Exposure, Stuart K Calderwood, Ayesha Murshid, Bangmin Zhu and Salamatu Mambula; 6 Mycobacterial Heat Shock Protein 60s in the Induction and Regulation of Infectious Disease, Anthony R. M. Coates, Ann Cehovin and Yanmin Hu; 7 Heat Shock Proteins in Protozoan Parasites - Leishmania spp., Gabi Ommen and Joachim Clos; 8 Toll-Like Receptors and Infectious Diseases: Role of Heat Shock Proteins, Punit Kaur and Alexzander A. A. Asea; 9 Lipid Rafts, Lipopolysaccharide and Stress Proteins in Infectious Disease, Martha Triantafilou, Daniel Thomas Sawyer and Kathy Triantafilou; 10 Heat Shock Proteins are Mediators of Bacterial-Host Interactions, Brian Henderson; 11 Membrane-Expressed and Extracellular Stress Proteins in Infectious Disease, Gabriele Multhoff; 12 Circulating Stress Proteins in Infectious Disease, Rose Njemini and Tony Mets; 13 Heat Shock Proteins, Genital Tract Infections and Reproductive Outcome , Steven S. Witkin and Iara Moreno Linhares; 14 Heat Shock Proteins and Oral Diseases: Special Focus on Periodontitis, Anders Gustafsson, A. Graham Pockley and Kåre Buhlin; 15 Temperature Matters: Cellular Targets of Hyperthermia in Cancer Biology and Immunology, Melissa J. Grimm, Evan R. Zynda and Elizabeth A. Repasky; Index.