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  • Reference work
  • © 2013

Drug Design

Methodology, Concepts, and Mode-of-Action

Editors:

  1. Gerhard Klebe

    1. Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany

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  • Unique reference work on the subject of drug design
  • Full colours throughout
  • Intelligibly written and illustrated containing over 100 computer graphics
  • Including an index of about 5,000 items

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Table of contents (32 entries)

  1. Front Matter

    Pages i-xv
    PDF

  2. Part I Fundamentals in Drug Research

    1. Front Matter

      Pages 1-2
      PDF

    3. In the Beginning, There Was Serendipity

      • Gerhard Klebe
      Pages 23-36

    4. Classical Drug Research

      • Gerhard Klebe
      Pages 37-60

    6. Optical Activity and Biological Effect

      • Gerhard Klebe
      Pages 89-110

  3. Part II The Search for the Lead Structure

    1. Front Matter

      Pages 111-112
      PDF

    2. The Classical Search for Lead Structures

      • Gerhard Klebe
      Pages 113-128

    4. Optimization of Lead Structures

      • Gerhard Klebe
      Pages 153-172

    5. Designing Prodrugs

      • Gerhard Klebe
      Pages 173-188

    6. Peptidomimetics

      • Gerhard Klebe
      Pages 189-208

  4. Part III Experimental and Theoretical Methods

    1. Front Matter

      Pages 209-210
      PDF

    2. Combinatorics: Chemistry with Big Numbers

      • Gerhard Klebe
      Pages 211-232

    3. Gene Technology in Drug Research

      • Gerhard Klebe
      Pages 233-264

    5. Three-Dimensional Structure of Biomolecules

      • Gerhard Klebe
      Pages 291-314

    6. Molecular Modeling

      • Gerhard Klebe
      Pages 315-334

    7. Conformational Analysis

      • Gerhard Klebe
      Pages 335-346
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About this book

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design. Structures by mode of action, no therapeutic areas. Of high relevance for academia and industrial research. Focus on gene technology in drug design, omics-technologies computational methods experimental techniques of structure determination multiple examples on mode of action of current drugs, ADME-tox properties in drug development, QSAR methods, combinatorial chemistry, biologicals, ribosome, targeting protein-protein interfaces.
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Keywords

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Editors and Affiliations

  • Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Marburg, Germany

    Gerhard Klebe

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About the editor

Well-known author has won a prize for the German edition of this work.
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Bibliographic Information

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Societies and partnerships

Access via your institution

Buy it now

eBook USD 649.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 949.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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