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  • © 2009

The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

Authors:

  1. Michail S. Davidoff

    1. Anatomisches Institut, Univ.Klinikum Hamburg, Hamburg, Germany

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  2. Ralf Middendorff

    1. FB Medizin, Universitätsklinikum Gießen, Gießen, Germany

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  3. D. Müller

    1. FB Medizin, Universitätsklinikum Gießen, Gießen, Germany

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  4. Adolf F. Holstein

    1. Krankenhaus Eppendorf, Universitätsklinikum Hamburg, Hamburg, Germany

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 205)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
    PDF

  2. Introduction

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 1-2

  3. History of and Recent Progress in Leydig Cell Research

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 3-8

  4. Morphology of the Leydig Cells

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 9-18

  5. The Well-Known Endocrine Function of the Leydig Cells

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 19-21

  6. The Neuroendocrine Properties of the Leydig Cells

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 23-43

  7. Development of the Testis

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 45-48

  8. Development of the Neuroendocrine Leydig Cells

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 49-87

  9. Fetal and Adult Leydig Cells Are of Common Orig

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 89-103

  10. Concluding Remarks

    • Michail S. Davidoff, Ralf Middendorff, Dieter Müller, Adolf F. Holstein
    Pages 105-107

  11. Back Matter

    Pages 109-154
    PDF
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About this book

cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes are distributed throughout the body, and there is convincing evidence for their stem/progenitor cell properties in diverse organs. Under appropriate (locally defined) conditions these pericytes, which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate towards different somatic cell types of the body. Since most mesenchymal stem/ progenitor cell types exhibit essential similarity to pericytes and certain mesenchymal stem cells represent pericyte descendants, we propose that mesenchymal stem cells in the perivascular niche are daughter cells of pericytes. Thus, pericytes are promising candidates for ancestor cells of all adult stem cells in the organism. There is strong evidence that early stem cells (cells arising during embryogenesis), such as the pericytes, exhibit both mesodermal and neural progeny, which might explain the neuroendocrine properties of the Leydig cells.
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Keywords

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Authors and Affiliations

  • Anatomisches Institut, Univ.Klinikum Hamburg, Hamburg, Germany

    Michail S. Davidoff

  • FB Medizin, Universitätsklinikum Gießen, Gießen, Germany

    Ralf Middendorff, D. Müller

  • Krankenhaus Eppendorf, Universitätsklinikum Hamburg, Hamburg, Germany

    Adolf F. Holstein

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Bibliographic Information

  • Book Title: The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes

  • Authors: Michail S. Davidoff, Ralf Middendorff, D. Müller, Adolf F. Holstein

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-642-00513-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2009

  • Softcover ISBN: 978-3-642-00512-1Published: 22 June 2009

  • eBook ISBN: 978-3-642-00513-8Published: 15 July 2009

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: X, 154

  • Number of Illustrations: 20 b/w illustrations, 2 illustrations in colour

  • Topics: Biomedicine general, Endocrinology

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Buy it now

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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