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Drug Discovery and Evaluation: Pharmacological Assays

  • Reference work
  • © 2016

Overview

Editors:
  1. Franz J. Hock

    1. CorDynamics, Dieburg, Germany

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  • Covers classical and cutting-edge technologies, including methods & assessment of relevance

  • Updates readers with some 1,000 assays in an easy-to-use and uniform Format

  • Guides readers on testing and evaluating pharmacological effects of potential new drugs

  • Includes supplementary material: sn.pub/extras

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Table of contents (147 entries)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. Cardiovascular Activity

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Studies in Isolated Organs

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 3-39

    3. Cardiovascular Analysis In Vivo

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 41-133

    4. Methods to Induce Experimental Hypertension

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 135-164

    5. Coronary Drugs

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 165-216

    6. Calcium Uptake Inhibition Activity

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 217-236

    7. Anti-Arrhythmic Activity

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 237-286

    8. Methods to Induce Cardiac Hypertrophy and Insufficiency

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 287-333

    9. Positive Inotropic Activity (Cardiac Glycosides)

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 335-347

    10. Effects on Blood Supply and on Arterial and Venous Tonus

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 349-428

    11. α- and β-Adrenoreceptor Binding

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 429-472

    12. Adenosine Receptor

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 473-496

    13. Different Channels

      • Liomar A. A. Neves, Olga Tiniakova
      Pages 497-511

    14. Effect of Different Peptides

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 513-553

    15. Na+/H+ Exchange

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 555-566

    16. NO Activity and Rho Kinase Activity

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 567-586

    17. PAF Binding and Endothelins Activity

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 587-610

    18. Patch-Clamp and Voltage-Clamp Techniques

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 611-644

    19. Phosphodiesterases and the Effects of Forskolin

      • Michael Gralinski, Liomar A. A. Neves, Olga Tiniakova
      Pages 645-663
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Keywords

About this book

The 4th edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal and immunomodulatory activities. Each of the more than 1,000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis, - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. New chapters are added such as Auditory Pharmacology, Oncology Activity, Stem Cells, Omics, Personalized Medicine, etc.

Editors and Affiliations

  • CorDynamics, Dieburg, Germany

    Franz J. Hock

About the editor

Since retiring from Aventis in 2002, Dr. Franz Jakob Hock has leveraged his experience as a freelance consultant specializing in Safety Pharmacology. Dr. Hock was a research scientist at Hoechst, Hoechst Marion Roussel and Aventis from 1976 – 2002. He lectured for several years at the University of Kassel und the Technical University of Darmstadt. Currently he is a member of the Task Force General/Safety Pharmacology German/Swiss Pharmaceutical Companies and a member of the Program Committee of the Safety Pharmacology Society.

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