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Biomedical Sciences | RNA Interference from Biology to Therapeutics

RNA Interference from Biology to Therapeutics

Howard, Kenneth A. (Ed.)

2013, XVI, 340 p.

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  • Addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches
  • Covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects
  • Discusses current delivery technologies to overcome both intracellular and extracellular barriers

The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.  

Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics.

Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation.

“RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.

Content Level » Research

Keywords » Gene Silencing - MicroRNA - Nanomedicine - Nanoparticles - RNA Interference (RNAi) - RNAi Clinical Trials - RNAi Therapeutics - Small interfering RNA (siRNA) - siRNA Delivery

Related subjects » Biomedical Sciences - Pharmacology & Toxicology

Table of contents 

RNA Interference Pathways and Therapeutic Exploitation RNA Interference.- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference.- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine.- Intracellular Delivery Considerations for RNAi Therapeutics.- Mucosal Delivery of RNAi Therapeutics.- Nanomedicines for Systemic Delivery of RNAi Therapeutics.- Lipidoids: A Combinatorial Approach to siRNA Delivery.- Polymeric Micelles for siRNA Delivery.- RNAi Therapeutic Delivery by Exosomes.- Aptamer-Mediated siRNA Targeting.- RNAi as Anti-Viral Therapy: The HIV-1 Case.- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication.- The Application of microRNAs in Cancer Diagnostics.- Therapeutic Application of miRNAs in Cancer.- Clinical Development of an Inhalable Anti-RSV siRNA Treatment.

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