Overview
- Practical, comprehensive volume for understanding new methodologies and applications used to determine biological structure
- Includes supplementary material: sn.pub/extras
Part of the book series: Biological Magnetic Resonance (BIMR, volume 29)
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Table of contents (11 chapters)
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Front Matter
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Iron–Sulfur-Containing Materials
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Front Matter
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Mononuclear Molybdenum Enzymes
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Front Matter
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MONONUCLEAR MOLYBDENUM ENZYMES
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Manganese-Containing Enzymes
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Front Matter
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Novel Metalloenzymes and Metalloproteins
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Front Matter
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NOVEL METALLOENZYMES AND METALLOPROTEINS
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Back Matter
Keywords
About this book
Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes.
This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.
Editors and Affiliations
About the editors
Prof. Graeme Hanson, located in the Centre for Magnetic Resonance at the University of Queensland, has applied a unique synergistic approach involving both theoretical and experimental aspects of multifrequency continuous wave and pulsed EPR spectroscopy to structurally (geometric and electronic) characterise the metal binding sites in metalloenzymes and transition metal ion complexes. The development and commercialisation of the XSophe-Sophe-XeprView (CW EPR) and Molecular Sophe(CW EPR, Pulsed EPR and ENDOR) computer simulation software suites has been crucial in the characterisation of these biological inorganic systems.
Dr. Lawrence J. Berliner is currently at the Department of Chemistry and Biochemistry, University of Denver, where he was Professor and Chair for the past 8 years. He retired from The Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He has been recognized by the International EPR Society with the Silver Medal for Biology/Medicine in 2000. He also received the Lifetime Achievement Award in Biological EPR Spectroscopy at EPR-2005. He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.
Bibliographic Information
Book Title: Metals in Biology
Book Subtitle: Applications of High-Resolution EPR to Metalloenzymes
Editors: Graeme Hanson, Lawrence Berliner
Series Title: Biological Magnetic Resonance
DOI: https://doi.org/10.1007/978-1-4419-1139-1
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag New York 2010
eBook ISBN: 978-1-4419-1139-1Published: 11 March 2010
Series ISSN: 0192-6020
Series E-ISSN: 2512-2215
Edition Number: 1
Number of Pages: XIX, 419
Topics: Biomedicine general, Materials Science, general, Biomedical Engineering and Bioengineering