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Myb Transcription Factors: Their Role in Growth, Differentiation and Disease

  • Book
  • © 2004

Overview

Editors:
  1. Jon Frampton

    1. Institute for Biomedical Research, Birmingham University Medical School, UK

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Part of the book series: Proteins and Cell Regulation (PROR, volume 2)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xxxi
    Download chapter PDF

  2. Evolution of Myb Proteins

    • Colin Davidson, Emily Ray, Joseph Lipsick
    Pages 1-33

  3. Drosophila Myb

    • Alisa L. Katzen
    Pages 35-64

  4. Essential And Diverse Roles For C-Myb Throughout T Cell Development

    • Kathleen Weston
    Pages 65-80

  5. Potential Roles For C-Myb Thoughout Early Lymphocyte Development

    • Timothy P. Bender
    Pages 81-105

  6. Involvement Of C-Myb In Red Cell And Megakaryocyte Development

    • Alexandros Vegiopoulos, Nikla R. Emambokus, Jon Frampton
    Pages 107-131

  7. C-Myb As A Key Player In The Control Of Myeloid Cell Differentiation

    • Sandrine Sarrazin, Michael H. Sieweke
    Pages 133-144

  8. Does C-Myb Have A Role In Haemopoietic Stem Cells And Multilineage Progenitors?

    • Nikla R. Emambokus, Jon Frampton
    Pages 145-161

  9. A-Myb In Development And Cancer

    • Ramana V. Tantravahi, Stacey J. Baker, E. Premkumar Reddy
    Pages 163-179

  10. B-Myb: A Highly Regulated Member Of The Myb Transcription Factor Family

    • Roger J. Watson
    Pages 181-199

  11. Regulation Of Mammalian Myb Gene Expression

    • Fiona J. Tavner
    Pages 201-221

  12. The C-Myb Dna Binding Domain

    • Kazuhiro Ogata, Tahir H. Tahirov, Shunsuke Ishii
    Pages 223-238

  13. Myb Partnerships

    • Xianming Mo, Elisabeth Kowenz-Leutz, Achim Leutz
    Pages 239-256

  14. Target Genes Of V-Myb And C-Myb

    • Karl-Heinz Klempnauer
    Pages 257-270

  15. The Microarray Big Bang

    • Scott A. Ness
    Pages 271-278

  16. The V-Myb Oncogene

    • Fan Liu, Scott A. Ness
    Pages 279-306

  17. C-Myb And Leukaemogenesis

    • Juraj Bies, Linda Wolff
    Pages 307-329

  18. The Involvement Of Myb In Vascular Injury

    • Cathy M. Holt, Nadim Malik
    Pages 331-349

  19. Repression Of Matrix Gene Expression By B-Myb

    • Claudia S. Hofmann, Gail E. Sonenshein
    Pages 351-366

  20. The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis

    • Robert G. Ramsay, Daniel Ciznadji, Gabriella Zupi
    Pages 367-388
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Keywords

About this book

This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.

Editors and Affiliations

  • Institute for Biomedical Research, Birmingham University Medical School, UK

    Jon Frampton

Bibliographic Information

  • Book Title: Myb Transcription Factors: Their Role in Growth, Differentiation and Disease

  • Editors: Jon Frampton

  • Series Title: Proteins and Cell Regulation

  • DOI: https://doi.org/10.1007/978-1-4020-2869-4

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media B.V. 2004

  • Hardcover ISBN: 978-1-4020-2779-6Published: 11 March 2005

  • Softcover ISBN: 978-90-481-6720-3Published: 25 December 2010

  • eBook ISBN: 978-1-4020-2869-4Published: 13 October 2007

  • Series ISSN: 1567-2530

  • Series E-ISSN: 2542-9973

  • Edition Number: 1

  • Number of Pages: XXXI, 415

  • Topics: Biomedicine general, Cancer Research, Hematology, Proteomics, Cell Biology, Developmental Biology

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