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This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
Preface List of contributors 1 Evolution Of Myb Proteins; Colin Davidson, Emily Ray and Joseph Lipsick 2 Drosophila Myb: Lessons for the Understanding of Vertebrate Myb Proteins; Alisa L. Katzen 3 Essential And Diverse Roles For C-Myb Throughout T Cell Development; Kathleen Weston 4 Potential Roles For C-Myb Thoughout Early Lymphocyte Development; Timothy P. Bender 5 Involvement Of C-Myb In Red Cell And Megakaryocyte Development; Alexandros Vegiopoulos, Nikla R. Emambokus, Jon Frampton 6 C-Myb As A Key Player In The Control Of Myeloid Cell Differentiation; Sandrine Sarrazin and Michael H. Sieweke 7 Does C-Myb Have A Role In Haemopoietic Stem Cells And Multilineage Progenitors? Nikla R. Emambokus and Jon Frampton 8 A-Myb In Development And Cancer; Ramana V. Tantravahi, Stacey J. Baker and E. Premkumar Reddy 9 B-Myb: A Highly Regulated Member Of The Myb Transcription Factor Family; Roger J. Watson 10 Regulation Of Mammalian Myb Gene Expression; Fiona J. Tavner 11 The C-Myb DNA Binding Domain From Molecular Structure to Function; Kazuhiro Ogata, Tahir H. Tahirov and Shunsuke Ishii 12 Myb Partnerships; Xianming Mo, Elisabeth Kowenz-Leutz and Achim Leutz 13 Target Genes Of V-Myb And C-Myb; Karl-Heinz Klempnauer 14 The Microarray Big Bang: Genome-Scale Identification of Myb Regulated Genes; Scott A. Ness 15 The V-Myb Oncogene: Two Models for Activation; Fan Liu and Scott A. Ness 16 C-Myb And Leukaemogenesis; Juraj Bies and Linda Wolff 17 The Involvement Of Myb In Vascular Injury; Cathy M. Holt and Nadim Malik 18 Repression Of Matrix Gene Expression By B-Myb; Claudia S. Hofmann and Gail E. Sonenshein 19 The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis; Robert G. Ramsay, Daniel Ciznadji and Gabriella Zupi 20 C-Myb And Creb Function In Adult Neurogenesis; Theo Mantamadiotis, SallyLightowler, Marijana Vanevski, Mark A. Rosenthal, Nikla R. Emambokus, Jon Frampton, Robert G. Ramsay 21 The C-Myb Gene: A Rational Target For Treatment Of Human Diseases; Susan E. Shetzline and Alan M. Gewirtz Authors index