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Molecular Control Mechanisms in Striated Muscle Contraction addresses the molecular mechanisms by which contraction of heart and skeletal muscles is regulated, as well as the modulation of these mechanisms by important (patho)physiological variables such as ionic composition of the myoplasm and phosphorylations of contractile and regulatory proteins. For the novice, this volume includes chapters that summarize current understanding of excitation-contraction coupling in striated muscles, as well as the compositions and structures myofibrillar thick and thin filaments. For the expert, this volume presents detailed pictures of current understanding of the mechanisms underlying the CA2+ regulation of contraction in heart and skeletal muscles and discusses important directions for future investigation.
Content Level »Research
Keywords »cardiac function - heart - molecular mechanisms - muscle - protein - proteins - regulation - skeletal muscle
Preface. Introduction; G. Stienen. Excitation-Contraction Coupling in Skeletal Muscle; A. Gonzalez, E. Rios. Excitation-Contraction Coupling In Cardiac Muscle; A.W. Trafford, D.A. Eisner. The Thick Filament of Vertebrate Striated Muscle; R.J.C. Levine, R.W. Kensler. Structure and Regulation of Cardiac and Skeletal Muscle Thin Filaments; L.S. Tobacman. Cation Signaling in Striated Muscle Contraction; A.V. Gomes, et al. Calcium-Induced Molecular and Structural Signaling in Striated Muscle Contraction; H.C. Cheung. Cooperativity in the Ca2+-regulation of Skeletal Muscle Contraction; M.A. Geeves, S.S. Lehrer. Regulation of the Rate of Force Development in Heart and Skeletal Muscles; R.L. Moss, et al. Modulation of Thin Filament Activity in Long and Short Term Regulation of Cardiac Function; R.J. Solaro, et al. Thin Filament Regulation in Development; P. Anderson. The Frank-Starling Relationship: Cellular and Molecular Mechanisms; F. Fuchs. Determinants of Unloaded Shortening Velocity in Striated Muscle; E. Homsher. Author index.