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Protein Structure, Stability, and Folding

  • Book
  • © 2001

Overview

Editors:
  1. Kenneth P. Murphy

    1. University of Iowa College of Medicine, Iowa City

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Part of the book series: Methods in Molecular Biology (MIMB, volume 168)

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Table of contents (10 protocols)

  1. Front Matter

    Pages i-ix
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  2. Stabilization of Protein Structure

    • Kenneth P. Murphy
    Pages 1-16

  3. Protein Stabilization by Naturally Occurring Osmolytes

    • D. Wayne Bolen
    Pages 17-36

  4. TheThermodynamic Linkage Between Protein Structure, Stability, and Function

    • Ernesto Freire
    Pages 37-68

  5. Measuring the Conformational Stability of a Protein by Hydrogen Exchange

    • Beatrice M. P. Huyghues-Despointes, C. Nick Pace, S. Walter Englander, J. Martin Scholtz
    Pages 69-92

  6. Modeling the Native State Ensemble

    • Vincent J. Hilser
    Pages 93-116

  7. Conformational Entropy in Protein Folding

    • Trevor P. Creamer
    Pages 117-132

  8. Turn Scanning

    • Carl Frieden, Enoch S. Huang, Jay W. Ponder
    Pages 133-158

  9. Laser Temperature-Jump Methods for Studying Folding Dynamics

    • James Hofrichter
    Pages 159-191

  10. Kinetics of Conformational Fluctuations by EX1 Hydrogen Exchange in Native Proteins

    • T. Sivaraman, Andrew D. Robertson
    Pages 193-214

  11. Molecular Dynamics Simulations of Protein Unfolding/Folding

    • Valerie Daggett
    Pages 215-247

  12. Back Matter

    Pages 249-252
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About this book

In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.

Reviews

"Both theoretical and experimental approaches for studying protein structure, stability, and folding are described in the book. The fundamental concepts are clearly presented....The topics on modeling and simulation would be useful for protein designers....The book starts with a concise overview on the fundamental thermodynamic concepts and governing forces for protein folding." - PHARMACEUTICAL RESEARCH

"focuses on the structure-stability relationship and in the well-balanced mixture of experimental and theoretical chapters, all of which are written by experts in the fields." - Chembiochem

Editors and Affiliations

  • University of Iowa College of Medicine, Iowa City

    Kenneth P. Murphy

Bibliographic Information

  • Book Title: Protein Structure, Stability, and Folding

  • Editors: Kenneth P. Murphy

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1385/1592591930

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2001

  • Hardcover ISBN: 978-0-89603-682-6Published: 01 April 2001

  • Softcover ISBN: 978-1-61737-132-5Published: 10 November 2010

  • eBook ISBN: 978-1-59259-193-0Published: 04 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: IX, 252

  • Topics: Biochemistry, general

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