Self and Nonself

1. Front Matter

   Pages i-xxi

   PDF

2. The Origin of the Bacterial Immune Response

   • Jesús Martínez-Borra, Segundo González, Carlos López-Larrea

   Pages 1-13

3. The Evolution of Self During the Transition to Multicellularity

   • Aurora M. Nedelcu

   Pages 14-30

4. Glyconectin Glycans as the Self-Assembling Nano-Molecular-Velcrosystem Mediating Self-Nonself Recognition and Adhesion Implicated in Evolution of Multicellularity

   • Gradimir N. Misevic, Nikola Misevic, Octavian Popescu

   Pages 31-45

5. Neglected Biological Features in Cnidarians Self-Nonself Recognition

   • Baruch Rinkevich

   Pages 46-59

6. Intracellular Inflammatory Sensors for Foreign Invaders and Substances of Self-Origin

   • Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita

   Pages 60-78

7. Nonself Perception in Plant Innate Immunity

   • Ian A. Dubery, Natasha M. Sanabria, Ju-Chi Huang

   Pages 79-107

8. How did Flowering Plants Learn to Avoid Blind Date Mistakes?

   • Philip J. Kear, Bruce McClure

   Pages 108-123

9. Signaling Pathways that Regulate Life and Cell Death: Evolution of Apoptosis in the Context of Self-Defense

   • Cristina Muñoz-Pinedo

   Pages 124-143

10. Sensing Necrotic Cells

    • Yasunobu Miyake, Sho Yamasaki

    Pages 144-152

11. Sensing Endoplasmic Reticulum Stress

    • Vipul M. Parmar, Martin Schröder

    Pages 153-168

12. Autophagy and Self-Defense

    • Jesús Martínez-Borra, Carlos López-Larrea

    Pages 169-184

13. Viruses and Host Evolution: Virus-Mediated Self Identity

    • Luis Villarreal

    Pages 185-217

14. The Evolution of Adaptive Immunity

    • Nadia Danilova

    Pages 218-235

15. Epigenetic Code and Self-Identity

    • Vincenzo Calvanese, Ester Lara, Mario F. Fraga

    Pages 236-255

16. Viral Immunomodulatory Proteins: Usurping Host Genes as a Survival Strategy

    • Pablo Engel, Ana Angulo

    Pages 256-276

17. The Emergence of the Major Histocompatilibility Complex

    • Jesús Martínez-Borra, Carlos López-Larrea

    Pages 277-289

18. MHC Signaling during Social Communication

    • James S. Ruff, Adam C. Nelson, Jason L. Kubinak, Wayne K. Potts

    Pages 290-313

19. Back Matter

    Pages 315-320

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In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

• Immunology
• López-Larrea
• Self-Nonself Recognition

• Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

  Carlos López-Larrea

Carlos López-Larrea is Professor of Immunology (Oviedo, Spain) and currently Head of the Department of Immunology at the Hospital Universitario Central de Asturias (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular genetic (MHC) and genetic factors that influence the development of the disease. The main research interests of his group also currently include the study of epigenetic mechanisms involved in autoimmune diseases and the role of innate immunity in organ transplantation tolerance. He is a member of several international scientific organizations and board member of different scientific journals. He has published more than 150 international papers and books related to immunology and spondylaorthropathies.

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