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Clinical Nephrotoxins

Renal Injury from Drugs and Chemicals

  • Book
  • © 2008

Overview

Editors:
  1. Marc E. Broe

    1. Laboratory of Pathophysiology Universiteitsplein 1, University of Antwerp, Wilrijk, Belgium

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  2. George A. Porter

    1. Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, USA

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  3. William M. Bennett

    1. Legacy Good Samaritan Hospital, Portland, USA

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  4. Gilbert Deray

    1. Groupe Hôspitalier Pitié Salpétrière Service De Néphrologie 83, Boulevard de l′Hôpital, Paris, France

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  • Premier reference on nephrotoxins

  • Includes supplementary material: sn.pub/extras

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Table of contents (44 chapters)

  1. Front Matter

    Pages i-xvii
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  2. General

    1. Clinical relevance

      • George A. Porter
      Pages 3-28

    2. Drug-associated acute kidney injury in the intensive care unit

      • Mitchell H. Rosner, Mark D. Okusa
      Pages 29-41

    3. Renal handling of drugs and xenobiotics

      • Marc E. De Broe, FranÇoise Roch-Ramel
      Pages 43-71

    4. Pharmacological aspects of nephrotoxicity

      • Marisa D. Covington, Rick G. Schnellmann
      Pages 73-83

    5. Pharmacovigilance: from signal to action

      • Hubert G. Leufkens, Antoine C. Egberts
      Pages 85-90

    6. Urinary biomarkers and nephrotoxicity

      • William F. Finn, George A. Porter
      Pages 92-130

    7. Toxin-induced immunological renal disease

      • Lucette Pelletier, Abdelhadi Saoudi, Gilbert Fournié
      Pages 131-153

    8. Cellular mechanisms of nephrotoxicity

      • Istvan Arany, Gur P. Kaushal, Didier Portilla, Judit Megyesi, Peter M. Price, Robert L. Safirstein
      Pages 155-170

    9. Animal models for the assessment of acute renal dysfunction and injury

      • Zoltan H. Endre, Charles L. Edelstein
      Pages 173-221

    10. Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms

      • Paul Jennings, Christian KoppelstÄtter, Judith Lechner, Walter Pfaller
      Pages 223-249

    11. Use of dialytic therapies for poisoning

      • James F. Winchester, Nikolas Harbord, Donald A. Feinfeld
      Pages 251-264

  3. Specific Drugs

    1. Aminoglycosides and vancomycin

      • Brian S. Decker, Bruce A. Molitoris
      Pages 267-292

    2. Beta-lactam antibiotics

      • Constantin Cojocel
      Pages 293-321

    3. Amphotericin B

      • Nathalie K. Zgheib, Blair Capitano, Robert A. Branch
      Pages 323-352

    4. Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones

      • Gabriel N. Contreras, Cristiane Mocelin Carvalho, Jorge M. Diego, Decio Carvalho, Isabel Espinal
      Pages 353-381

    5. Antiviral agents

      • Jeffrey S. Berns, Alden Doyle, Nishaminy Kasbekar
      Pages 383-398

    6. Analgesics and 5-aminosalicylic acid

      • Monique M. Elseviers, Marc E. De Broe
      Pages 399-417

    7. Non-steroidal anti-inflammatory drugs

      • Ali J. Olyaei, Andrew Whelton, Til Sturmer, George A. Porter
      Pages 419-457

    8. Gold salts, D-penicillamine and allopurinol

      • Shiro Ueda, George A. Porter
      Pages 459-479
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Keywords

About this book

Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. In addition, the volume highlights specific types of drugs, such as anti-infectious agents and anti-inflammatory, cardiovascular and anti-cancer drugs. The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this third and completely revised edition, several new topics were added and additional figures and tables will be included.

The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.

Reviews

From the reviews of the third edition:

"The purpose is to provide a guide with balanced and agreed-upon information about renal injury from drugs and chemicals. … This book is a useful source of information for general clinicians, and nephrologists in particular. Intensivists, pharmacists, and investigators will also find it quite helpful. … The book is well written, easy to read, and covers essential topics in a logical sequence. … This book is particularly useful for nephrologists and I highly recommend it to medical and hospital libraries." (Aziz Chami, Doody’s Review Services, February, 2009)

Editors and Affiliations

  • Laboratory of Pathophysiology Universiteitsplein 1, University of Antwerp, Wilrijk, Belgium

    Marc E. Broe

  • Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland, USA

    George A. Porter

  • Legacy Good Samaritan Hospital, Portland, USA

    William M. Bennett

  • Groupe Hôspitalier Pitié Salpétrière Service De Néphrologie 83, Boulevard de l′Hôpital, Paris, France

    Gilbert Deray

Bibliographic Information

  • Book Title: Clinical Nephrotoxins

  • Book Subtitle: Renal Injury from Drugs and Chemicals

  • Editors: Marc E. Broe, George A. Porter, William M. Bennett, Gilbert Deray

  • DOI: https://doi.org/10.1007/978-0-387-84843-3

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2008

  • Hardcover ISBN: 978-0-387-84842-6Published: 06 October 2008

  • Softcover ISBN: 978-1-4899-7728-1Published: 23 August 2016

  • eBook ISBN: 978-0-387-84843-3Published: 15 September 2008

  • Edition Number: 3

  • Number of Pages: XVII, 987

  • Topics: Nephrology, Internal Medicine

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