Overview
- by The University of Hong Kong as an outstanding Ph.D. thesis
- reviews the current status of gold- and platinum-based anti-cancer agents
- Highlights the significant advances made in the area of metal-based anti-cancer agents
- Includes original drug design, drug synthesis, cell-based bio-experiments and animal-based studies
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (6 chapters)
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Front Matter
Keywords
About this book
This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)
Book Subtitle: Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents
Authors: Taotao Zou
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-981-10-0657-9
Publisher: Springer Singapore
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Science+Business Media Singapore 2016
Hardcover ISBN: 978-981-10-0656-2Published: 02 March 2016
Softcover ISBN: 978-981-10-9221-3Published: 25 April 2018
eBook ISBN: 978-981-10-0657-9Published: 19 February 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIII, 164
Number of Illustrations: 100 b/w illustrations, 79 illustrations in colour
Topics: Inorganic Chemistry, Medicinal Chemistry, Molecular Medicine, Cancer Research