Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

1. Front Matter

   Pages i-xxiv

   PDF

2. Metal Carcinogenesis

   1. Zinc Finger-DNA Interaction: Effect of Metal Replacement, Free Radical Generation and DNA Damage and its Relevance to Carcinogenesis

      • B. Sarkar

      Pages 1-14

   2. Pathways in the Chromium(VI)-Mediated Formation of DNA Lesions: A Review

      • A. Kortenkamp, M. Casadevall, P. Da Cruz Fresco, R. O. J. Shayer

      Pages 15-34

   3. Approaches to the Biological Monitoring of Chromium(VI) Exposed Individuals

      • A. Kortenkamp

      Pages 35-53

   4. The Mechanisms of Metal Carcinogenicity

      • Diane M. Stearns, Karen E. Wetterhahn

      Pages 55-72

   5. The Oxidative Damage Hypothesis of Metal-Induced Genotoxicity and Carcinogenesis

      • K. S. Kasprzak

      Pages 73-92

   6. Effects of Calcium, Magnesium, Zinc, and Iron on Nickel Carcinogenesis: Inhibition Versus Enhancement

      • K. S. Kasprzak

      Pages 93-106

   7. Modeling the Metal Binding Sites in Core Histones: Interactions of Carcinogenic Ni(II) with the -CAIH- Motif of Histone H3

      • W. Bal, K. S. Kasprzak

      Pages 107-121

   8. Perinatal Effects of Metals and Cancer in Offspring

      • M. A. Sipowicz, B. A. Diwan, D. Ramljak, G. S. Buzard, W. Yu, M. P. Waalkes et al.

      Pages 123-138

3. Metallothioneins

   1. Spectroscopic Properties of Ag(I), Cd(II), Cu(I), Hg(II), and Zn(II) Metallothioneins

      • Martin J. Stillman

      Pages 139-194

   2. Diversity of Cluster Structures in Mammalian Metallothionein: Interplay Between Metal Ions and Polypeptide Chain

      • M. Vašák, R. Bogumil

      Pages 195-215

   3. Metallothionein in Cytotoxicity and Genotoxicity of Metals

      • M. George Cherian, Peter J. Ferguson

      Pages 217-229

4. Biological Role of Aluminium

   1. Aluminium(III) Speciation and Biological Effects

      • P. Zatta, P. Zambenedetti

      Pages 231-240

   2. Interaction of Al(III) with Biomolecules: Bioinorganic Chemistry and Biological Implication

      • Tamas Kiss, Andrea Lakatos, Erzsebet Kiss, R. Bruce Martin

      Pages 241-251

   3. Complexes of Aluminium(III) with Biologically Important Ligands

      • A. L. Petrou, M. Kollia, A.-I. Scourti, M. Chrycikopoulou, T. Mavromoystakos, E. Theodoropoulou et al.

      Pages 253-263

5. Bioinorganic Chemistry (General)

   1. Bioinorganic Aspects of Lanthanide(III) Coordination Chemistry: Modelling the Use of Lanthanides(III) as Probes at Calcium(II) Binding Sites

      • Spyros P. Perlepes

      Pages 265-272

   2. From the Mass Production of Methylococcus Capsulatus to the Efficient Separation and Isolation of Methane Monooxygenase Proteins. Characterization of Novel Intermediates in Substrate Reactions of Methane Monooxygenase

      • Katherine E. Liu, Ann M. Valentine, Danli Wang, Boi H. Huynh, Dale E. Edmondson, Athanasios Salifoglou et al.

      Pages 273-286

   3. Modeling Manganese Redox Enzymes

      • Dimitris P. Kessissoglou

      Pages 287-309

6. Metal Transport

   1. Li+ Transport Properties in Perfused Neuronal Cells by 7Li NMR Spectroscopy

      • M. M. C. A. Castro, J. Nikolakopoulos, C. Zachariah, D. M. de Freitas, C. F. G. C. Geraldes, R. Ramasamy

      Pages 311-321

   2. Active Efflux Mechanisms for Cellular Resistance

      • A. Garnier-Suillerot

      Pages 323-347

Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity.
The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.

• Inorganic Chemistry
• Nucleotide
• carcinogenesis
• chemistry
• environment
• environmental pollution
• health
• mutagen
• organic chemistry
• pollution
• transport
• tumor
• air pollution and air quality

• Laboratory of Inorganic and General Chemistry, Department of Chemistry, University of Ioannina, Ioannina, Greece

  Nick D. Hadjiliadis

Policies and ethics