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Side Effects of Anti-Inflammatory Drugs IV

The Proceedings of the IVth International Meeting on Side Effects of Anti-inflammatory Drugs, held in Sheffield, UK, 7–9 August 1995

  • Conference proceedings
  • © 1997

Overview

Editors:
  1. K. D. Rainsford

    1. Division of Biomedical Sciences, School of Science and Medicine, Sheffield Hallam University, Sheffield, UK

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Table of contents (52 papers)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Current Status of Side-Effects from Anti-Inflammatory Drugs

      • K. D. Rainsford
      Pages 3-7

  3. Clinico-Epidemiological Aspects

    1. Front Matter

      Pages 9-9
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    2. The Placebo Response: Clinical Efficacy and Toxicity

      • W. W. Buchanan, N. Bellamy
      Pages 11-23

    3. Side-Effects of Non-Steroidal Anti-Inflammatory Drugs: Studies from the Tayside Medicines Monitoring Unit

      • T. M. MacDonald
      Pages 25-30

    4. Treatment Decisions, Side-Effect Liability and Cost-Effectiveness in Osteoarthritis

      • G. E. Ehrlich
      Pages 31-34

    5. Measuring Beneficial and Adverse Events in Osteoarthritis Clinical Trials

      • N. Bellamy
      Pages 35-42

    6. Do NSAIDs Adversely Affect Joint Pathology in Osteoarthritis?

      • F. S. Walker, K. D. Rainsford
      Pages 43-53

    7. Safety of Non-Steroidal Anti-Inflammatory Drugs during Pregnancy and Lactation

      • M. E. Østensen
      Pages 55-65

    8. Side-Effects from Biologics in the Therapy of Rheumatic Diseases

      • J. D. Isaacs
      Pages 67-76

    9. Oral Tolerance from a General Perspective, and the Possible Role of Side-Effects in the Gut

      • A. Mitchison, U. Gimsa, J. Sieper
      Pages 77-80

    10. Summary of Debate

      • K. D. Rainsford
      Pages 81-84

  5. Gastrointestinal Tract — Clinical Aspects

    1. Front Matter

      Pages 119-119
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    2. Intestinal Pathology from NSAIDs

      • F. Halter, A. Gut, C. Ruchti
      Pages 121-138

    3. A Clinician’s View of Strategies for Preventing Nsaid-Induced Gastrointestinal Ulcers

      • J. Huang, R. H. Hunt
      Pages 139-152
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Keywords

About this book

Recent concern about the adverse effects and relative risks of anti- inflammatory therapies has been such that another meeting was organized in the highly successful series of meetings on this topic. Adverse effects of anti-rheumatic and anti-inflammatory drugs are of major concern to all involved in the prescription, care and management of rheumatic and other patients receiving these important drugs. The IVth International Meeting on Side-Effects of Anti-Inflammatory Drugs, held in Sheffield, UK, 7-9 August 1995, afforded a unique opportunity to hear the latest information and views on issues concerning the development of adverse effects from these drugs, the management of these effects, and the development of safer therapies.
In addition to discussions on the safety relative to efficacy of established non-steroidal and steroidal anti-inflammatory drugs and disease-modifying agents, there was detailed consideration of the novel cyclo-oxygenase-2 selective NSAIDs which have recently been developed and introduced to the clinic. Also, the side effects from therapy with biologics, notably monoclonal antibodies and oral tolerance therapies, were considered.
Among the other highlights in the programme were:
  • Clinico-epidemiological studies on the adverse effects relative to use/efficacy of established and new anti-rheumatic drugs.
  • Procedures for reducing the gastrointestinal adverse effects.
  • Mechanisms and clinical significance of adverse effects in the gastrointestinal tract, liver, kidney, articular joints, skin and other organs from NSAIDs.
  • Clinical status and mechanisms of action of the newer (third generation) of NSAIDs (e.g. etodolac, nabumetone, meloxicam).
  • Medico-legal aspects of adverse effects from anti-rheumatic drugs.
  • The concept of `conditional pharmacology' or the disease-dependence of the toxicological and pharmacological activity of the anti-inflammatory drugs.

The papers in this book were selected from those presented at the meeting.

Editors and Affiliations

  • Division of Biomedical Sciences, School of Science and Medicine, Sheffield Hallam University, Sheffield, UK

    K. D. Rainsford

Bibliographic Information

  • Book Title: Side Effects of Anti-Inflammatory Drugs IV

  • Book Subtitle: The Proceedings of the IVth International Meeting on Side Effects of Anti-inflammatory Drugs, held in Sheffield, UK, 7–9 August 1995

  • Editors: K. D. Rainsford

  • DOI: https://doi.org/10.1007/978-94-011-5394-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1997

  • Hardcover ISBN: 978-0-7923-8713-8Published: 30 April 1997

  • Softcover ISBN: 978-94-010-6269-5Published: 05 November 2012

  • eBook ISBN: 978-94-011-5394-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 356

  • Topics: Rheumatology, Pharmacology/Toxicology

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