Mechanics of Elastic Biomolecules

1. Front Matter

   Pages i-vii

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2. DNA, Chromatin and Chromosomes

   1. Front Matter

      Pages 365-365

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   2. Mechanics and imaging of single DNA molecules

      • M. Hegner, W. Grange

      Pages 367-375

   3. Stretching and imaging single DNA molecules and chromatin

      • Jordanka Zlatanova, Sanford H. Leuba

      Pages 377-395

   4. Optical tweezers stretching of chromatin

      • Lisa H. Pope, Martin L. Bennink, Jan Greve

      Pages 397-407

   5. Micromechanical studies of mitotic chromosomes

      • M. G. Poirier, J. F. Marko

      Pages 409-431

3. Elastic Invertebrate Muscle Proteins

   1. Front Matter

      Pages 433-433

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   2. Varieties of elastic protein in invertebrate muscles

      • Belinda Bullard, Wolfgang A. Linke, Kevin Leonard

      Pages 435-447

   3. Single-molecule measurement of elasticity of Serine-, Glutamate- and Lysine-Rich repeats of invertebrate connectin reveals that its elasticity is caused entropically by random coil structure

      • Atsushi Fukuzawa, Michio Hiroshima, Koscak Maruyama, Naoto Yonezawa, Makio Tokunaga, Sumiko Kimura

      Pages 449-453

4. The Elastic Vertebrate Muscle Protein Titin

   1. Front Matter

      Pages 455-455

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   2. Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology

      • Henk Granzier, Dietmar Labeit, Yiming Wu, Siegfried Labeit

      Pages 457-471

   3. Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension

      • Marion L. Greaser, Mustapha Berri, Chad M. Warren, Paul E. Mozdziak

      Pages 473-482

   4. Cardiac titin: molecular basis of elasticity and cellular contribution to elastic and viscous stiffness components in myocardium

      • Wolfgang A. Linke, Julio M. Fernandez

      Pages 483-497

   5. Stretching and visualizing titin molecules: combining structure, dynamics and mechanics

      • Miklós S. Z. Kellermayer, László Grama

      Pages 499-511

   6. Unfolding of titin domains studied by molecular dynamics simulations

      • Mu Gao, Hui Lu, Klaus Schulten

      Pages 513-521

5. Cytoskeletal Proteins

   1. Front Matter

      Pages 523-523

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   2. Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton

      • Masahito Yamazaki, Shou Furuike, Tadanao Ito

      Pages 525-534

   3. Mechanics of vimentin intermediate filaments

      • Ning Wang, Dimitrijie Stamenovic

      Pages 535-540

6. Extracellular Matrix Proteins

   1. Front Matter

      Pages 541-541

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   2. Mechanics of elastin: molecular mechanism of biological elasticity and its relationship to contraction

      • D. W. Urry, T. M. Parker

      Pages 543-559

A representative cross-section of elastic biomolecules is covered in this volume, which combines seventeen contributions from leading research groups. State-of-the-art molecular mechanics experiments are described dealing with the elasticity of DNA and nucleoprotein complexes, titin and titin-like proteins in muscle, as well as proteins of the cytoskeleton and the extracellular matrix.
The book speaks particularly to cell biologists, biophysicists, or bioengineers, and to senior researchers and graduate students alike, who are interested in recent advances in single-molecule technology (optical tweezers technique, atomic force microscopy), EM imaging, and computer simulation approaches to study nanobiomechanics. The findings discussed here have redefined our view of the role mechanical signals play in cellular functions and have greatly helped improve our understanding of biological elasticity in general.

• DNA
• Glutamat
• biomechanics
• pathophysiology
• physiology
• protein complexes
• proteins

• University of Heidelberg, Heidelberg, Germany

  Wolfgang A. Linke

• Washington State University, Pullman, USA

  Henk Granzier

• University of Pécs, Pécs, Hungary

  Miklós S. Z. Kellermayer

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