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Interrelationship Among Aging, Cancer and Differentiation

Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29–May 2, 1985

  • Conference proceedings
  • © 1985

Overview

Editors:
  1. Bernard Pullman

    1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

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  2. Paul O. P. Ts’o

    1. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, USA

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  3. Edmond L. Schneider

    1. National Institute on Aging, National Institutes of Health, Bethesda, USA

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Part of the book series: Jerusalem Symposia (JSQC, volume 18)

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Table of contents (31 papers)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Interrelationships Among Aging, Cancer and Differentiation

    • Edward L. Schneider
    Pages 1-5

  3. Deceleration of Cancer Mortality Rates with Age and Time

    • Jacob A. Brody, Donald F. Everett Jr.
    Pages 7-13

  4. Clinical Aspects of Cancer in the Elderly

    • Harvey Jay Cohen
    Pages 15-21

  5. Overview of the Pathobiology of Aging

    • George M. Martin
    Pages 23-34

  6. Regulators of Growth, Differentiation and the Reversal of Malignancy

    • Leo Sachs
    Pages 35-42

  7. Transforming Genes of Human Malignancies

    • Alessandra Eva, Stuart A. Aaronson, Steven R. Tronick
    Pages 43-57

  8. Cancer Cells as Probes of Embryonic Development

    • G. Barry Pierce, Robert S. Wells
    Pages 59-65

  9. Alterations in Epidermal Differentiation in Skin Carcinogenesis

    • Stuart H. Yuspa
    Pages 67-81

  10. Virus Transformation as a Function of Age, Differentiation and Hereditary Factors

    • W. H. Kirsten
    Pages 83-86

  11. Negative Control of Viral and Cellular Enhancer Activity by the Products of the Immortalizing E1A Gene of Human Adenovirus-2

    • Emiliana Borrelli, René Hen, Pierre Chambon
    Pages 87-99

  12. Expression of Two Murine Gene Families in Transformed Cells and Embryogenesis

    • Jeffrey A. Moshier, Richard A. Morgan, Ru Chih C. Huang
    Pages 101-116

  13. Methotrexate Resistance, Gene Amplification, and Somatic Cell Heterogeneity

    • Robert T. Schimke
    Pages 117-120

  14. Macromolecular Correlates of Cellular Senescence and Cancer

    • Robert J. Shmookler Reis, Arun Srivastava, Samuel Goldstein
    Pages 121-132

  15. Dominance of In Vitro Senescence in Somatic Cell Hybridization and Biochemical Experiments

    • James R. Smith, Olivia M. Pereira-Smith
    Pages 133-141

  16. Studies on Gene Structure and Function in Aging: Collagen Types I and II and the Albumin Genes

    • D. Gershon, K. Kohno, G. R. Martin, Y. Yamada
    Pages 143-148

  17. Retrovirus-Like Gene Families in Normal Cells: Potential for Affecting Cellular Gene Expression

    • E. Keshet, A. Itin, G. Rotman
    Pages 149-161

  18. The Conformational Effects of UV Induced Damage on DNA

    • David A. Pearlman, Stephen R. Holbrook, Sung-Hou Kim
    Pages 163-171

  19. DNA Supercoiling and Gene Expression

    • James C. Wang
    Pages 173-181

  20. Intermediates in Transcription Initiation and Propagation

    • David C. Straney, Donald M. Crothers
    Pages 183-186
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Keywords

About this book

In 1980. a distinguished group of scientists gathered In Washington. D. C. for an International Symposium on Aging and Cancer. Among the recommendations of this Symposium was to convene a future meeting to discuss the molecular basis for Interrelationships between aging and cancer when the appropriate scientific knowledge was available. That same year. the 13th Jerusalem Symposium on Quantum Chemistry and Biochemistry entitled ·Carcl­ nogenesls : Fundamental Mechanisms and Environmental Effects·. was held. attended by some 50 International authorities In this field. At this meeting. It became clear that the fundamental process of carcinogenesis 15 Intimately associated with differentiation. which must also be mechanistically related to aging. It was therefore proposed that the next Jerusalem Symposium on Cancer could provide the appropriate forum for the study on the Interrelationship among cancer. aging and differentiation. The Impressive advances In our knowledge of the nature of the genome through molecular genetic and physical chemical techniques have now provided the opportunity to examine the Interrelationships between these complex biolo­ gical processes. Through the Isolation. cloning and rearranging of genes we are able to dissect and manipulate the genome In a fashion that was unanticipated only a decade ago. At the same time. the Increase In longevity and the Increased numbers of Individuals entering the last decades of life where cancer Incidences are highest raise the profound and practical question of whether aging and cancer are linked through common mechanisms.

Editors and Affiliations

  • Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  • Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, USA

    Paul O. P. Ts’o

  • National Institute on Aging, National Institutes of Health, Bethesda, USA

    Edmond L. Schneider

Bibliographic Information

  • Book Title: Interrelationship Among Aging, Cancer and Differentiation

  • Book Subtitle: Proceedings of the Eighteenth Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, Israel, April 29–May 2, 1985

  • Editors: Bernard Pullman, Paul O. P. Ts’o, Edmond L. Schneider

  • Series Title: Jerusalem Symposia

  • DOI: https://doi.org/10.1007/978-94-009-5466-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: D. Reidel Publishing Company, Dordrecht, Holland 1985

  • Hardcover ISBN: 978-90-277-2117-4Published: 30 November 1985

  • Softcover ISBN: 978-94-010-8913-5Published: 02 October 2011

  • eBook ISBN: 978-94-009-5466-3Published: 06 December 2012

  • Series ISSN: 0924-4875

  • Edition Number: 1

  • Number of Pages: X, 345

  • Topics: Physical Chemistry

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