Bioinformatics of Human Proteomics

1. Front Matter

   Pages i-xiii

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2. Clinical Bioinformatics in Human Proteomics Research

   • Duojiao Wu, Haihao Li, Xiangdong Wang

   Pages 1-15

3. Proteomics Defines Protein Interaction Network of Signaling Pathways

   • Shitao Li

   Pages 17-38

4. Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation

   • Jessica Duarte, Jean-Michel Serufuri, Nicola Mulder, Jonathan Blackburn

   Pages 39-74

5. Proteomics and Cancer Research

   • Elena Lopez Villar, William Chi-Shing Cho

   Pages 75-101

6. Toward Development of Novel Peptide-Based Cancer Therapeutics: Computational Design and Experimental Evaluation

   • Elena Pirogova, Taghrid Istivan

   Pages 103-126

7. Advances in Proteomic Methods

   • Xianyin Lai

   Pages 127-167

8. Clinical and Biomedical Mass Spectrometry: New Frontiers in Drug Developments and Diagnosis

   • Ákos Végvári, Melinda Rezeli, David Erlinge, György Marko-Varga

   Pages 169-185

9. Disease Biomarkers: Modelling MR Spectroscopy and Clinical Applications

   • Luis Martí-Bonmatí, A. Alberich-Bayarri

   Pages 187-205

10. Processing of Mass Spectrometry Data in Clinical Applications

    • Dario Di Silvestre, Pietro Brunetti, Pier Luigi Mauri

    Pages 207-233

11. Bioinformatics Approach for Finding Target Protein in Infectious Disease

    • Hemant Ritturaj Kushwaha, Indira Ghosh

    Pages 235-255

12. Identification of Network Biomarkers for Cancer Diagnosis

    • Jiajia Chen, Luonan Chen, Bairong Shen

    Pages 257-275

13. Software Development for Quantitative Proteomics Using Stable Isotope Labeling

    • Xin Huang, Shi-Jian Ding

    Pages 277-294

14. Clinical Translation of Protein Biomarkers Integrated with Bioinformatics

    • Xu Yang, Juanjuan Zhou, Chaoqin Du

    Pages 295-308

15. Proteomic Approaches for Urine Biomarker Discovery in Bladder Cancer

    • Ming-Hui Yang, Yu-Chang Tyan

    Pages 309-329

16. Antibody Microarrays and Multiplexing

    • Jerry Zhou, Larissa Belov, Nicola Armstrong, Richard I. Christopherson

    Pages 331-359

17. Proteomics in Anaesthesia and Intensive Care Medicine

    • Ornella Piazza, Giuseppe De Benedictis, Geremia F. Zito Marinosci

    Pages 361-376

18. Erratum

    • Elena Pirogova, Taghrid Istivan

    Pages E1-E1

19. Back Matter

    Pages 377-390

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“Bioinformatics of Human Proteomics” discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics. It collects contributions from expert researchers in order to provide a practical guide to this complex field of study. The book covers the protein interaction network, drug discovery and development, the relationship between translational medicine and bioinformatics, and advances in proteomic methods, while also demonstrating important bioinformatics tools and methods available today for protein analysis, interpretation and predication. It is intended for experts or senior researchers in the fields of clinical research-related biostatistics, bioinformatics, computational biology, medicine, statistics, system biology, molecular diagnostics, biomarkers, or drug discovery and development. Dr.Xiangdong Wang works as a distinguished professor of Respiratory Medicine at Fudan University, Shanghai, China. He serves as Director of Biomedical Research Center, Fudan University Zhongshan Hospital and adjunct professor of Clinical Bioinformatics at Lund University, Sweden. His main research is focused on the role of clinical bioinformatics in the development of disease-specific biomarkers and dynamic network biomarkers, the molecular mechanism of organ dysfunction and potential therapies.

• clinical bioinformatics
• mass spectrometry
• protein interaction network
• proteomics analysis
• proteomics bioinformatics
• translational research
• Proteomics
• Systems Biology

• , Medicine, Biomedical Research Center, Fudan University Zhongshan Hospital, Shang Hai, China, People's Republic

  Xiangdong Wang

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