MicroRNA Cancer Regulation

1. Front Matter

   Pages i-xii

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2. MicroRNAs in Human Cancer

   • Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl

   Pages 1-20

3. Bioinformatics, Non-coding RNAs and Its Possible Application in Personalized Medicine

   • Simona Rossi, George A. Calin

   Pages 21-37

4. MicroRNA Target Prediction and Validation

   • William Ritchie, John E. J. Rasko, Stéphane Flamant

   Pages 39-53

5. MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology

   • Julio Vera, Xin Lai, Ulf Schmitz, Olaf Wolkenhauer

   Pages 55-76

6. The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches

   • Sabine Hünten, Helge Siemens, Markus Kaller, Heiko Hermeking

   Pages 77-101

7. MicroRNAs in Melanoma Biology

   • Manfred Kunz

   Pages 103-120

8. MicroRNAs in the Lung

   • Alexandra Sittka, Bernd Schmeck

   Pages 121-134

9. The E2F1-miRNA Cancer Progression Network

   • Susanne Knoll, Stephan Emmrich, Brigitte M. Pützer

   Pages 135-147

10. Modeling microRNA-Transcription Factor Networks in Cancer

    • Baltazar D. Aguda

    Pages 149-167

11. Coordinated Networks of microRNAs and Transcription Factors with Evolutionary Perspectives

    • Hisakazu Iwama

    Pages 169-187

12. Mathematical Modeling of microRNA–Mediated Mechanisms of Translation Repression

    • Andrei Zinovyev, Nadya Morozova, Alexander N. Gorban, Annick Harel-Belan

    Pages 189-224

13. Web Resources for microRNA Research

    • Ulf Schmitz, Olaf Wolkenhauer

    Pages 225-250

14. Discovery of microRNA Regulatory Networks by Integrating Multidimensional High-Throughput Data

    • Jian-Hua Yang, Liang-Hu Qu

    Pages 251-266

15. Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data

    • Bing Liu, Lin Liu, Anna Tsykin, Gregory J. Goodall, Murray J. Cairns, Jiuyong Li

    Pages 267-290

16. Elucidating the Role of microRNAs in Cancer Through Data Mining Techniques

    • Luciano Cascione, Alfredo Ferro, Rosalba Giugno, Alessandro Laganà, Giuseppe Pigola, Alfredo Pulvirenti et al.

    Pages 291-315

17. Working Together: Combinatorial Regulation by microRNAs

    • Yitzhak Friedman, Ohad Balaga, Michal Linial

    Pages 317-337

18. Erratum

    • Thalia A. Farazi, Jessica I. Hoell, Pavel Morozov, Thomas Tuschl

    Pages E1-E1

19. Back Matter

    Pages 339-346

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This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

• bioinformatics
• cancer regulation
• gene regulation
• microRNA
• systems biology
• gene expression

• Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

  Ulf Schmitz

• Dept. of Systems Biology and Bioinformat, Universität Rostock Institut of Computer Science, Rostock, Germany

  Olaf Wolkenhauer

• Rostock, Germany

  Julio Vera

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