Overview
- Includes step-by-step procedures and practical tips for different isotope labeling methods
- Covers the entire gamut of biomolecular NMR spectroscopy
- Includes emerging areas such as structure/dynamics of large proteins, metabolomics and solid state NMR
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 992)
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Table of contents (11 chapters)
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Front Matter
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Proteins
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Front Matter
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PROTEINS
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Nucleic Acids
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Front Matter
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Metabolomics
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Front Matter
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METABOLOMICS
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Expression Systems
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Front Matter
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Back Matter
Keywords
About this book
NMR spectroscopy has undergone a revolution in recent years with the advent of several new methods overcoming the problems of sensitivity and resolution. Recent developments in biotechnology have made it easier and economical to introduce 13C, 15N and 2H into proteins and nucleic acids. At the same time, there has been an explosion in the number of NMR experiments that utilize such isotope labeled samples. Thus, a combination of isotopic labeling and multidimensional, multinuclear NMR has opened up new avenues for structural studies of proteins, nucleic acids and their complexes.
This book will focus on recent developments in isotope labeling methods for structural studies of small molecules, peptides, proteins and nucleic acids. The aim of the book is to serve as a compendium of isotope labeling for the biomolecular NMR community providing comprehensive coverage of the existing methods and latest developments along with protocols and practical hints on the various experimental aspects. The book will cover a wide range of topics in isotope labeling under one title including emerging areas of metabolonomics and solid state NMR.
Editors and Affiliations
Bibliographic Information
Book Title: Isotope labeling in Biomolecular NMR
Editors: Hanudatta S. Atreya
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-94-007-4954-2
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2012
Hardcover ISBN: 978-94-007-4953-5Published: 18 October 2012
Softcover ISBN: 978-94-024-0646-7Published: 23 August 2016
eBook ISBN: 978-94-007-4954-2Published: 18 October 2012
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 219
Topics: Biomedicine general, Spectroscopy/Spectrometry, Biotechnology, Biological Techniques, Life Sciences, general