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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

  • Book
  • © 2012

Overview

Editors:
  1. Denis J. Dupré

    1. Faculty of Medicine, Pharmacology, Dalhousie University, Halifax, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Terence E. Hébert

    1. , Pharmacology and Therapeutics, McGill University, Montreal, Canada

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    You can also search for this editor in PubMed   Google Scholar

  3. Ralf Jockers

    1. Institut Cochin, Paris, France

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  • This is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes
  • Several colors images
  • Compilations of manuscripts made from experts in the field

Part of the book series: Subcellular Biochemistry (SCBI, volume 63)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. ER-Bound Steps in the Biosynthesis of G Protein-Coupled Receptors

    • Christian Nanoff, Michael Freissmuth
    Pages 1-21

  3. Role of Chaperones in G Protein Coupled Receptor Signaling Complex Assembly

    • Denis J. Dupré, Maha M. Hammad, Patrick Holland, Jaime Wertman
    Pages 23-42

  4. GPCR Oligomerization: Contribution to Receptor Biogenesis

    • Kathleen Van Craenenbroeck
    Pages 43-65

  5. The Functional Size of GPCRs – Monomers, Dimers or Tetramers?

    • Darlaine Pétrin, Terence E. Hébert
    Pages 67-81

  6. Regulation of Post-Golgi Traffic of G Protein-Coupled Receptors

    • Guangyu Wu
    Pages 83-95

  7. Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Example

    • Hamasseh Shirvani, Gabriel Gätà, Stefano Marullo
    Pages 97-111

  8. Regulatory Processes Governing the Cell Surface Expression of LH and FSH Receptors

    • Deborah L. Segaloff
    Pages 113-129

  9. Chaperone-Mediated Assembly of G Protein Complexes

    • Barry M. Willardson, Christopher M. Tracy
    Pages 131-153

  10. Synthesis and Assembly of G Protein βγ Dimers: Comparison of In Vitro and In Vivo Studies

    • Jane Dingus, John D. Hildebrandt
    Pages 155-180

  11. Preferential Assembly of G-αβγ Complexes Directed by the γ Subunits

    • Janet D. Robishaw
    Pages 181-191

  12. G Protein Trafficking

    • Philip B. Wedegaertner
    Pages 193-223

  13. Differential Assembly of GPCR Signaling Complexes Determines Signaling Specificity

    • Pascal Maurice, Abla Benleulmi-Chaachoua, Ralf Jockers
    Pages 225-240

  14. GPCR and Voltage-Gated Calcium Channels (VGCC) Signaling Complexes

    • Christophe Altier
    Pages 241-262

  15. Pharmacological Chaperones Correct Misfolded GPCRs and Rescue Function: Protein Trafficking as a Therapeutic Target

    • Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick, P. Michael Conn
    Pages 263-289

  16. Back Matter

    Pages 291-299
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Keywords

About this book

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Editors and Affiliations

  • Faculty of Medicine, Pharmacology, Dalhousie University, Halifax, Canada

    Denis J. Dupré

  • , Pharmacology and Therapeutics, McGill University, Montreal, Canada

    Terence E. Hébert

  • Institut Cochin, Paris, France

    Ralf Jockers

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