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Systems Metabolic Engineering

  • Book
  • © 2012

Overview

Editors:
  1. Christoph Wittmann

    1. Inst. Bioverfahrenstechnik, TU Braunschweig, Braunschweig, Germany

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  2. Sang Yup Lee

    1. Science and Technology-KAIST, Dept. Biosystems a. Bioinformatics, Korea Advanced Institute, Daejeon, Korea, Republic of (South Korea)

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    You can also search for this editor in PubMed   Google Scholar

  • State-of-art approaches with industrial relevance
  • Combines and integrates in silico and experimental strategies Internationally leading author consortium
  • Explains tools and techniques

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. Genome-Scale Network Modeling

    • Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth et al.
    Pages 1-23

  3. Kinetic Modeling of Metabolic Networks

    • Daniel C. Zielinski, Bernhard Ø. Palsson
    Pages 25-55

  4. Design of Superior Cell Factories Based on Systems Wide Omics Analysis

    • Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu
    Pages 57-81

  5. Technologies for Biosystems Engineering

    • Sonja Billerbeck, Sven Dietz, Gaspar Morgado, Sven Panke
    Pages 83-115

  6. Systems Metabolic Engineering of Escherichia coli for Chemicals, Materials, Biofuels, and Pharmaceuticals

    • Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, Sang Yup Lee
    Pages 117-149

  7. Systems Metabolic Engineering of Corynebacterium glutamicum for Biobased Production of Chemicals, Materials and Fuels

    • Judith Becker, Stefanie Kind, Christoph Wittmann
    Pages 151-191

  8. Towards a Synthetic Biology of the Stress-Response and the Tolerance Phenotype: Systems Understanding and Engineering of the Clostridium acetobutylicum Stress-Response and Tolerance to Toxic Metabolites

    • Eleftherios T. Papoutsakis, Keith V. Alsaker
    Pages 193-219

  9. Model-Based Design of Superior Cell Factory: An Illustrative Example of Penicillium chrysogenum

    • I. Emrah Nikerel, Peter J. T. Verheijen, Walter M. van Gulik, Joseph J. Heijnen
    Pages 221-270

  10. Bridging Omics Technologies with Synthetic Biology in Yeast Industrial Biotechnology

    • António Roldão, Il-Kwon Kim, Jens Nielsen
    Pages 271-327

  11. Design of Superior Cell Factories for a Sustainable Biorefinery By Synthetic Bioengineering

    • Tomohisa Hasunuma, Fumio Matsuda, Akihiko Kondo
    Pages 329-348

  12. Systems-Level Analysis of Cancer Metabolism

    • Paulo A. Gameiro, Christian M. Metallo, Gregory Stephanopoulos
    Pages 349-381

  13. Back Matter

    Pages 383-387
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Keywords

About this book

Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production.

Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises.

This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Editors and Affiliations

  • Inst. Bioverfahrenstechnik, TU Braunschweig, Braunschweig, Germany

    Christoph Wittmann

  • Science and Technology-KAIST, Dept. Biosystems a. Bioinformatics, Korea Advanced Institute, Daejeon, Korea, Republic of (South Korea)

    Sang Yup Lee

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