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Epigenetics: Development and Disease

  • Book
  • © 2013

Overview

Editors:
  1. Tapas K. Kundu

    1. Advanced Scientific Research, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for, Bangalore, India

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  • Role of genome organisation as a basic platform of different epigenetic phenomena in the pathophysiological context
  • Epigenetic regulation of transcription Epigenetic contribution in development
  • Epigenetic mechanisms of important diseases such as diabetes, AIDS, Alzheimer?s disease, malaria and cancer Furthermore, the book has also revealed the epigenetic phenomena as target of new generation therapeutics

Part of the book series: Subcellular Biochemistry (SCBI, volume 61)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Epigenetics and Evolution

    1. Front Matter

      Pages 1-1
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  3. EPIGENETICS AND EVOLUTION

    1. Chromatin Organization, Epigenetics and Differentiation: An Evolutionary Perspective

      • Sujata Kumari, Amrutha Swaminathan, Snehajyoti Chatterjee, Parijat Senapati, Ramachandran Boopathi, Tapas K. Kundu
      Pages 3-35

    2. Secondary Structures of the Core Histone N-terminal Tails: Their Role in Regulating Chromatin Structure

      • Louis L. du Preez, Hugh-G. Patterton
      Pages 37-55

    3. Megabase Replication Domains Along the Human Genome: Relation to Chromatin Structure and Genome Organisation

      • Benjamin Audit, Lamia Zaghloul, Antoine Baker, Alain Arneodo, Chun-Long Chen, Yves d’Aubenton-Carafa et al.
      Pages 57-80

    4. Role of DNA Methyltransferases in Epigenetic Regulation in Bacteria

      • Ritesh Kumar, Desirazu N. Rao
      Pages 81-102

  4. Developmental Epigenetics

    1. Front Matter

      Pages 103-103
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  5. DEVELOPMENTAL EPIGENETICS

    1. Metabolic Aspects of Epigenome: Coupling of S-Adenosylmethionine Synthesis and Gene Regulation on Chromatin by SAMIT Module

      • Kazuhiko Igarashi, Yasutake Katoh
      Pages 105-118

    2. Epigenetic Regulation of Male Germ Cell Differentiation

      • Oliver Meikar, Matteo Da Ros, Noora Kotaja
      Pages 119-138

    3. Epigenetic Regulation of Skeletal Muscle Development and Differentiation

      • Narendra Bharathy, Belinda Mei Tze Ling, Reshma Taneja
      Pages 139-150

    4. Small Changes, Big Effects: Chromatin Goes Aging

      • Asmitha Lazarus, Kushal Kr. Banerjee, Ullas Kolthur-Seetharam
      Pages 151-176

    5. Homeotic Gene Regulation: A Paradigm for Epigenetic Mechanisms Underlying Organismal Development

      • Navneet K. Matharu, Vasanthi Dasari, Rakesh K. Mishra
      Pages 177-207

  6. Epigenetics and Transcription Regulation

    1. Front Matter

      Pages 209-209
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  7. EPIGENETICS AND TRANSCRIPTION REGULATION

    1. Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes

      • Sarah J. Goodfellow, Joost C. B. M. Zomerdijk
      Pages 211-236

    2. The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context

      • Maria J. Barrero, Sohail Malik
      Pages 237-259

    3. RNA Polymerase III Transcription – Regulated by Chromatin Structure and Regulator of Nuclear Chromatin Organization

      • Chiara Pascali, Martin Teichmann
      Pages 261-287

    4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in Humans

      • Jaime L. Miller, Patrick A. Grant
      Pages 289-317

    5. Histone Variants and Transcription Regulation

      • Cindy Law, Peter Cheung
      Pages 319-341

    6. Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View

      • Karthigeyan Dhanasekaran, Sujata Kumari, Chandrasekhar Kanduri
      Pages 343-372

    7. Chromatin Structure and Organization: The Relation with Gene Expression During Development and Disease

      • Benoît Moindrot, Philippe Bouvet, Fabien Mongelard
      Pages 373-396
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Keywords

About this book

Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to establish the epigenetic regulation of gene expression in physiological and pathophysiological conditions. This volume presents contributions from worldwide experts presenting their research and findings, including: the evolution of epigenetic machineries from archaea to higher eukaryotes; role of epigenetics in development and transcription regulation; epigenetic landscape of human disease; a chemical biology approach to understanding epigenetic phenomena; exploration of different small molecules as epigenetic therapies. This volume is aimed at students and researchers of chromatin biology and epigenetics and will also be of interest to a broader pharmaceutical audience.

Editors and Affiliations

  • Advanced Scientific Research, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for, Bangalore, India

    Tapas K. Kundu

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