Overview
- Editors:
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Patrizia Agostinis
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Dept Molec Cell Bio, K.U. Leuven, B-3000 Leuven, Belgium
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Samali Afshin
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School of Natural Science, Department of Biochemistry, NUI Galway, Galway, Ireland
- Comprehensive cover of the latest developments in ER stress
- Up to date and succinct description of the role of ER stress in pathophysiology
- Novel aspects of ER stress physiology never discussed before
- Includes supplementary material: sn.pub/extras
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Table of contents (19 chapters)
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Cellular Responses to ER Stress
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- Sandra JM Healy, Tom Verfaillie, Richard Jäger, Patrizia Agostinis, Afshin Samali
Pages 3-22
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- Jared Q Gerlach, Shashank Sharma, Kirk J Leister, Lokesh Joshi
Pages 23-39
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- Tom Verfaillie, Richard Jäger, Afshin Samali, Patrizia Agostinis
Pages 41-73
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- Riccardo Filadi, Enrico Zampese, Tullio Pozzan, Paola Pizzo, Cristina Fasolato
Pages 75-106
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- Tim Vervliet, Santeri Kiviluoto, Geert Bultynck
Pages 107-142
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- Danielle E. Read, Ananya Gupta, Karen Cawley, Sanjeev Gupta
Pages 143-161
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- MarÃa Salazar, Sonia Hernández-Tiedra, Mar Lorente, Guillermo Velasco
Pages 163-184
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- Mohammed Bensellam, Patrick Gilon, Jean-Christophe Jonas
Pages 185-211
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ER stress in physiological & pathological conditions
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Front Matter
Pages 205-205
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- Fumihiko Urano, Bryan O’Sullivan-Murphy
Pages 215-230
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- Sana Basseri, Richard C. Austin
Pages 231-256
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- Abhishek D. Garg, Agnieszka Kaczmarek, Dmitri V. Krysko, Peter Vandenabeele
Pages 257-279
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- Michal F. Tomczak, Arthur Kaser, Richard S. Blumberg
Pages 281-298
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- Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano
Pages 299-321
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- Han-Jou Chen, Jackie de Belleroche
Pages 323-337
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- Jody Groenendyk, Marek Michalak
Pages 339-355
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- Stéphanie Lhomond, Eric Chevet
Pages 357-382
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- Ethel R. Pereira, Amanda M. Preston, Linda M. Hendershot
Pages 383-412
About this book
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Editors and Affiliations
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Dept Molec Cell Bio, K.U. Leuven, B-3000 Leuven, Belgium
Patrizia Agostinis
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School of Natural Science, Department of Biochemistry, NUI Galway, Galway, Ireland
Samali Afshin