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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

  • Book
  • © 2012

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Editors:
  1. Rudolf Toman

    1. Institute of Virology, Dept. of Rickettsiology, Slovak Academy of Sciences, Bratislava, Slovakia

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  2. Robert A. Heinzen

    1. Rocky Mountain Laboratories, Coxiella Pathogenesis Section, NIH/NIAID, Hamilton, USA

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  3. James E. Samuel

    1. , Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M, College Station, USA

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  4. Jean-Louis Mege

    1. Institut Fédératif de Recherche 48, Les Maladies Infect Transmissibles, CNRS-IRD UMR 6236, Marseille, Cedex 05, France

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  • Provides the reader interesting insights into highly infectious intracellular pathogen Coxiella burnetii, the causative agent of Q fever, summarized by several leading groups in the field
  • Includes the newest data, techniques, and methodologies that have substantially transformed our understanding of the pathogen
  • Useful for microbiologists as well as veterinarians, physicians and health authorities involved in clinical medicine, emerging disease surveillance and biodefense.

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. History and Prospects of Coxiella burnetii Research

    • Karim E. Hechemy
    Pages 1-11

  3. Phylogenetic Diversity, Virulence and Comparative Genomics

    • Erin J. van Schaik, James E. Samuel
    Pages 13-38

  4. Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche

    • Katja Mertens, James E. Samuel
    Pages 39-63

  5. Lipopolysaccharide of Coxiella burnetii

    • Craig T. Narasaki, Rudolf Toman
    Pages 65-90

  6. Components of Protective Immunity

    • Guoquan Zhang, Yan Zhang, James E. Samuel
    Pages 91-104

  7. Proteome of Coxiella burnetii

    • Robert Ihnatko, Edward Shaw, Rudolf Toman
    Pages 105-130

  8. Coxiella Subversion of Intracellular Host Signaling

    • S. Kauser Hussain, Daniel E. Voth
    Pages 131-140

  9. The Coxiella burnetii Parasitophorous Vacuole

    • Eric Ghigo, María I. Colombo, Robert A. Heinzen
    Pages 141-169

  10. Coxiella burnetii Secretion Systems

    • Justin A. McDonough, Hayley J. Newton, Craig R. Roy
    Pages 171-197

  11. Role of Lipids in Coxiella burnetii Infection

    • Stacey D. Gilk
    Pages 199-213

  12. Axenic Growth of Coxiella burnetii

    • Anders Omsland
    Pages 215-229

  13. Developmental Biology of Coxiella burnetii

    • Michael F. Minnick, Rahul Raghavan
    Pages 231-248

  14. Genetic Manipulation of Coxiella burnetii

    • Paul A. Beare
    Pages 249-271

  15. Role of Innate and Adaptive Immunity in the Control of Q Fever

    • Christian Capo, Jean-Louis Mege
    Pages 273-286

  16. Immune Response and Coxiella burnetii Invasion

    • Amira Ben Amara, Yassina Bechah, Jean-Louis Mege
    Pages 287-298

  17. Antigenic Analysis for Vaccines and Diagnostics

    • Laura R. Hendrix, Chen Chen
    Pages 299-328

  18. Epidemic Q Fever in Humans in the Netherlands

    • Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever, Mirjam H. A. Hermans, Alexander C. A. P. Leenders et al.
    Pages 329-364

  19. Coxiella-like Endosymbionts

    • Jianmin Zhong
    Pages 365-379

  20. Molecular Typing of Coxiella burnetii (Q Fever)

    • Robert F. Massung, Sally J. Cutler, Dimitrios Frangoulidis
    Pages 381-396
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Keywords

About this book

Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

Editors and Affiliations

  • Institute of Virology, Dept. of Rickettsiology, Slovak Academy of Sciences, Bratislava, Slovakia

    Rudolf Toman

  • Rocky Mountain Laboratories, Coxiella Pathogenesis Section, NIH/NIAID, Hamilton, USA

    Robert A. Heinzen

  • , Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M, College Station, USA

    James E. Samuel

  • Institut Fédératif de Recherche 48, Les Maladies Infect Transmissibles, CNRS-IRD UMR 6236, Marseille, Cedex 05, France

    Jean-Louis Mege

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