Mortalin Biology: Life, Stress and Death

1. Front Matter

   Pages 1-1

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2. Structure and Function of Mortalin

   1. Front Matter

      Pages 1-1

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   2. Birth of Mortalin: Multiple Names, Niches and Functions Connecting Stress, Senescence and Cancer

      • Renu Wadhwa, Sunil C. Kaul

      Pages 3-20

   3. Mortalin’s Machinery

      • Custer C. Deocaris, Sunil C. Kaul, Renu Wadhwa

      Pages 21-30

   4. The Role of Mortalin in Iron Homeostasis

      • Wen-I Luo, James A. Cowan

      Pages 31-54

   5. Functional Characteristics of Mortalin

      • Walter A. Baseler, Tara L. Croston, John M. Hollander

      Pages 55-80

3. Mortalin in Evolution2 Deocaris

   1. Front Matter

      Pages 81-81

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   2. Mortalin and Drosophila DmHsp22: Two Mitochondrial Chaperones Regulating Aging and Carcinogenesis

      • Marie Le Pécheur, Geneviève Morrow, Robert M. Tanguay

      Pages 83-95

   3. Mortalin in Invertebrates and The Induction of Apoptosis by Wild-Type p53 Following Defeat of Mortalin-Based Cytoplasmic Sequestration in Cancerous Clam Hemocytes

      • Charles W. Walker, Ben Low, S. Anne Böttger

      Pages 97-113

   4. Mortalin and Stem Cells: A Study from Planarians

      • Renata Batistoni

      Pages 115-126

4. Mortalin in Health and Disease

   1. Front Matter

      Pages 127-127

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   2. Mortalin in Cell Protection from Immune Attack

      • Moran Saar, Oren Moskovich, Zvi Fishelson

      Pages 129-137

   3. Mortalin in Neurological Diseases

      • Jinghua Jin, Jing Zhang, Travis J. Cook, Jake G. Hoekstra

      Pages 139-158

   4. Loss of Mortalin Function in Parkinson’s Disease-Supporting the Mitochondrial Pathway of Neurodegeneration

      • Lena F. Burbulla, Rejko Krüger

      Pages 159-177

   5. Hsp75/mortalin and Protection from Ischemic Brain Injury

      • Robin E. White, Yi-Bing Ouyang, Rona G. Giffard

      Pages 179-190

   6. Catecholamine Regulated Protein (CRP40), A Splice Variant of Mortalin-2: Functional Role in CNS Disorders

      • Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa, Ram K. Mishra

      Pages 191-207

   7. Chaperonopathies: Diseases in Which Mortalin and Other Hsp-Chaperones Play a Role in Etiology and Pathogenesis

      • Alberto J. L. Macario, Francesco Cappello, Everly Conway de Macario

      Pages 209-221

5. Mortalin and Cancer

   1. Front Matter

      Pages 223-223

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   2. Many Faces of Mortalin and Tid1

      • Ohad Iosefson, Abdussalam Azem

      Pages 225-244

   3. Mortalin: A Positive Regulator of Centrosome Duplication and Amplification

      • Masayuki Kanai, Kenji Fukasawa

      Pages 245-255

The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.

• Cancer
• Mortalin
• Neurological disease
• Stress Protein
• Therapy

• National Institute of Advanced Industria, Tsukuba, Japan

  Sunil C. Kaul

• Science & Technology (AIST), National Insitute of Advanced Industrial, Tsukuba, Japan

  Renu Wadhwa

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