Stem Cells and Cancer Stem Cells, Volume 2

1. Front Matter

   Pages i-xxiv

   PDF

2. Stem Cells

   1. Front Matter

      Pages 1-1

      PDF

   2. Isolation of Bone Marrow Stromal Cells from Bone Marrow by Using a Filtering Device (Method)

      • Tomoki Aoyama, Junya Toguchida

      Pages 3-12

   3. Hematopoietic Stem Cell Frequency Estimate: Statistical Approach to Model Limiting Dilution Competitive Repopulation Assays

      • Thierry Bonnefoix, Mary Callanan

      Pages 13-26

   4. Characteristics of Cord Blood Stem Cells: Role of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP)

      • Massoumeh Ebtekar, Somayeh Shahrokhi, Kamran Alimoghaddam

      Pages 27-36

   5. A New Concept of Stem Cell Disorders, and the Rationale for Transplantation of Normal Stem Cells

      • Susumu Ikehara

      Pages 37-42

   6. Differentiation of Human Embryonic Stem Cells into Functional Hepatocyte-Like Cells (Method)

      • Takamichi Ishii

      Pages 43-49

   7. Stem Cell Mobilization: An Overview

      • Alessandro Isidori, Giuseppe Visani

      Pages 51-60

   8. Status and Impact of Research on Human Pluripotent Stem Cells: Cell Lines and Their Use in Published Research

      • Peter Löser, Anke Guhr, Sabine Kobold, Anna M. Wobus, Andreas Kurtz

      Pages 61-74

   9. Gliosarcoma Stem Cells: Glial and Mesenchymal Differentiation

      • Ana C. deCarvalho, Tom Mikkelsen

      Pages 75-81

   10. Generation of Induced Pluripotent Stem Cells from Mesenchymal Stromal Cells Derived from Human Third Molars (Method)

       • Yasuaki Oda, Hiroe Ohnishi, Shunsuke Yuba, Hajime Ohgushi

       Pages 83-93

   11. Self-renewal and Differentiation of Intestinal Stem Cells: Role of Hedgehog Pathway

       • Nikè V.J.A. Büller, Sanne L. Rosekrans, Gijs R. van den Brink

       Pages 95-102

   12. Hematopoietic Stem Cell Repopulation After Transplantation: Role of Vinculin

       • Tsukasa Ohmori, Yoichi Sakata

       Pages 103-110

   13. Static and Suspension Culture of Human Embryonic Stem Cells

       • Guoliang Meng, Derrick Rancourt

       Pages 111-118

   14. Generation of Marmoset Induced Pluripotent Stem Cells Using Six Transcription Factors (Method)

       • Ikuo Tomioka, Erika Sasaki

       Pages 119-125

   15. MYC as a Multifaceted Regulator of Pluripotency and Reprogramming

       • Keriayn N. Smith, Stephen Dalton

       Pages 127-134

3. Cancer Stem Cells

   1. Front Matter

      Pages 135-135

      PDF

   2. Human Thyroid Cancer Stem Cells

      • Veronica Catalano, Antonina Benfante, Giorgio Stassi, Matilde Todaro

      Pages 137-143

   3. Tumor Stem Cells: CD133 Gene Regulation and Tumor Stemness

      • Kouichi Tabu, Tetsuya Taga, Shinya Tanaka

      Pages 145-153

   4. Cripto-1: A Common Embryonic Stem Cell and Cancer Cell Marker

      • Maria Cristina Rangel, Nadia P. Castro, Hideaki Karasawa, Tadahiro Nagaoka, David S. Salomon, Caterina Bianco

      Pages 155-166

As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, cord blood stem cells, human pluripotent stem cells, gliosarcoma stem cells, induced pluripotent stem cells, intestinal stem cells, human thyroid cancer stem cells, tumor stem cells, menstrual stem-like cells, neural stem cells, breast cancer stem cells, allogeneic mesenchymal stem cells, fetal membrane-derived mesemchynmal stem cells, and omental stem cells. The method for isolating bone marrow stromal cells is explained. Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. Use of stem cell lines in therapeutic applications is discussed. Programming of stem cells is described. Methods for transplantation of stem cells are presented. Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier’s disease, and neurogenerative diseases in general, is explained. For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. Differentiation of new neurons from neural stem cells is described. Method for repairing retina condition using human embryonic stem cells is explained; these cells can induce neural differentiation. Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated.

• Cancer stem cells
• Disease treatment
• Regenerative medicine
• Stem cells
• Tissue engineering
• thoracic surgery

From the reviews:

“Stem cells and cancer stem cells are 2 distinct, evolving, and promising areas of research. … This book, the second in a planned series of 7 volumes, covers select new research in both fields. This book highlights selected research from renowned scientists around the world. … Stem Cells and Cancer Stem Cells would be most helpful for basic science researchers studying stem cells and for cancer stem cell preclinical research.” (Paulette Mehta, Journal of the American Medical Association, Vol. 307 (10), March, 2012)

“This well-written book not only describes current laboratory techniques for studying stem cells, but also summarizes important aspects of the clinical potential of stem cell-based therapy in cancerous and noncancerous human diseases. … a much-needed update of the progress made in major areas of stem cell research applied to clinical medicine. … written for specialists and experts in different areas of clinical medicine, it is an excellent reference and guide for students and basic researchers with a particular interest in this promising and expanding field.” (Luigi Strizzi, Doody’s Review Service, March, 2012)

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