Mitochondrial Dynamics and Neurodegeneration

1. Front Matter

   Pages i-xii

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2. The Genetics of Mitochondrial Fusion and Fission

   • Eliana Y. L. Chan, Jarungjit Rujiviphat, G. Angus McQuibban

   Pages 1-46

3. Relationships Between Mitochondrial Dynamics and Bioenergetics

   • Giovanni Benard, Nadège Bellance, Caroline Jose, Rodrigue Rossignol

   Pages 47-68

4. Mitochondrial Dynamics and Autophagy

   • Linsey Stiles, Andrew Ferree, Orian Shirihai

   Pages 69-108

5. Mitochondrial Dynamics and Apoptosis

   • Megan M. Cleland, Richard J. Youle

   Pages 109-138

6. Mitochondrial Dynamics and Axonal Transport

   • Qian Cai, Zu-Hang Sheng

   Pages 139-168

7. Neurological Diseases Associated with Mutations in the Mitochondrial Fusion Machinery

   • Guy Lenaers, Dominique Bonneau, Cécile Delettre, Patrizia Amati-Bonneau, Emmanuelle Sarzi, Dan Miléa et al.

   Pages 169-196

8. Mitochondrial Fission-Fusion and Parkinson’s Disease: A Dynamic Question of Compensatory Networks

   • Charleen T. Chu, Sarah B. Berman

   Pages 197-213

9. Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration

   • Tomohiro Nakamura, Dong-Hyung Cho, Stuart A. Lipton

   Pages 215-234

10. Mitochondrial Dynamics and Huntington’s Disease: A Dance of Fate

    • Hongmin Wang, Mariusz Karbowski, Mervyn J. Monteiro

    Pages 235-257

11. Back Matter

    Pages 259-260

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Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

• Apoptosis
• Axonal transport
• Mitochondrial Fission and fusion
• Mitophagy
• Neurodegenerative diseases

From the reviews:

“The roles of various genes in the process of neurodegeneration is studied and published within this volume. The book ir primarily for biochemists, neuroscientists, and geneticists at all levels of training. I recommend it without any reservations.” (Joseph Grenier, Amazon.com, October, 2013)

• , Department of Pathology, Stanford University School of Medicine, Stanford, USA

  Bingwei Lu

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