Handbook of Schizophrenia Spectrum Disorders, Volume I

1. Front Matter

   Pages i-xvii

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2. The Schizophrenia Construct After 100 Years of Challenges

   • Michael S. Ritsner, Irving I. Gottesman

   Pages 1-44

3. Diagnosis and Classification of the Schizophrenia Spectrum Disorders

   • Daniel Mamah, Deanna M. Barch

   Pages 45-83

4. Toward a Multidimensional Continuum Model of Functional Psychoses for Research Purposes

   • Michael S. Ritsner

   Pages 85-113

5. Irving Gottesman and the Schizophrenia Spectrum

   • Aksel Bertelsen

   Pages 115-125

6. Schizotypy: Reflections on the Bridge to Schizophrenia and Obstacles on the Road Ahead to Etiology and Pathogenesis

   • Mark F. Lenzenweger

   Pages 127-141

7. Autistic Spectrum Disorders and Schizophrenia

   • Yael Dvir, Vishal Madaan, Lauren Yakutis, Jean A. Frazier, Daniel R. Wilson

   Pages 143-162

8. One Hundred Years of Insanity: Genomic, Psychological, and Evolutionary Models of Autism in Relation to Schizophrenia

   • Bernard J. Crespi

   Pages 163-185

9. Quantifying the Dynamics of Central Systemic Degeneration in Schizophrenia

   • Anca R. Rădulescu

   Pages 187-217

10. Schizophrenia Has a High Heritability, but Where Are the Genes?

    • Patrick P. McDonald, Shiva M. Singh

    Pages 219-236

11. Changes in Gene Expression in Subjects with Schizophrenia Associated with Disease Progression

    • Brian Dean, Andrew Gibbons, Elizabeth Scarr, Elizabeth A. Thomas

    Pages 237-251

12. Amino Acids in Schizophrenia – Glycine, Serine and Arginine

    • Glen B. Baker, Jaime E.C. Hallak, Alexandria F. Dilullo, Lisa Burback, Serdar M. Dursun

    Pages 253-262

13. Developmental Consequences of Prenatal Exposure to Maternal Immune Activation

    • Stefanie L. Bronson, Neil M. Richtand

    Pages 263-285

14. Glutamatergic Neurotransmission Abnormalities and Schizophrenia

    • Yogesh Dwivedi, Ghanshyam N. Pandey

    Pages 287-304

15. Mathematical Models in Schizophrenia

    • Zhen Qi, Gary W. Miller, Eberhard O. Voit

    Pages 305-325

16. Methamphetamine-Associated Psychosis: A Model for Biomarker Discovery in Schizophrenia

    • Chad A. Bousman, Stephen J. Glatt, Ian P. Everall, Ming T. Tsuang

    Pages 327-343

17. What Does Proteomics Tell Us About Schizophrenia?

    • Daniel Martins-de-Souza, Wagner F. Gattaz, Emmanuel Dias-Neto

    Pages 345-366

18. The Role of 3α-Hydroxy-5α-Pregnan-20-One in Mediating the Development and/or Expression of Schizophrenia Spectrum Disorders: Findings in Rodents Models and Clinical Populations

    • Cheryl A. Frye, Danielle C. Llaneza

    Pages 367-404

19. Neural Substrates of Emotion Dysfunctions in Patients with Schizophrenia Spectrum Disorders

    • Katharina D. Pauly, Ute Habel

    Pages 405-429

20. Brain Morphological Abnormalities at the Onset of Schizophrenia and Other Psychotic Disorders: A Review of the Evidence

    • Antonio Vita, Luca De Peri, Cesare Turrina, Emilio Sacchetti

    Pages 431-443

A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.

• Clinical presentations
• Endophenotype
• Neuroscience
• Schizophrenia spectrum disorders
• Treatment and outcomes

• Sha'ar Menashe Mental Health Center, Hadera, Israel

  Michael S. Ritsner

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