Signal Transduction in Cancer Metastasis

1. Front Matter

   Pages i-xi

   PDF

2. Overview of Signal Transduction in Tumor Metastasis

   • Wen-Sheng Wu, Jia-Ru Wu

   Pages 1-8

3. Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways

   • Wen-Sheng Wu, Chi-Tan Hu

   Pages 9-24

4. The ERK1/2 MAP Kinase Signaling Pathway in Tumor Progression and Metastasis

   • Laure Voisin∗, Stéphanie Duhamel∗, Sylvain Meloche

   Pages 25-40

5. Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis

   • Alexey Shiryaev, Marijke Van Ghelue, Ugo Moens

   Pages 41-76

6. Grb2 and Other Adaptor Proteins in Tumor Metastasis

   • Alessio Giubellino, Praveen R. Arany

   Pages 77-102

7. The Role of ROS Signaling in Tumor Progression

   • Wen-Sheng Wu, Jia-Ru Wu

   Pages 103-118

8. Signal Cross Talks for Sustained MAPK Activation and Cell Migration Mediated by Reactive Oxygen Species: The Involvement in Tumor Progression

   • Chi-Tan Hu, Jia-Ru Wu, Wen-Sheng Wu

   Pages 119-136

9. Insights into the Dynamics of Focal Adhesion Protein Trafficking in Invasive Cancer Cells and Clinical Implications

   • Moulay A. Alaoui-Jamali, Krikor Bijian, Panagiota Toliopoulos

   Pages 137-155

10. Notch Signaling in Cancer Metastasis

    • Pingyu Zhang, Patrick A. Zweidler-McKay

    Pages 157-174

11. New Concepts on the Critical Functions of Cancer- and Metastasis-Initiating Cells in Treatment Resistance and Disease Relapse: Molecular Mechanisms, Signaling Transduction Elements and Novel Targeting Therapies

    • Murielle Mimeault, Surinder K. Batra

    Pages 175-207

12. Involvement of Lipid Rafts in Growth Factor Receptors-Mediated Signaling for Cancer Metastasis

    • Samir Kumar Patra

    Pages 209-224

13. Cadherin-Catenin Signaling in Ovarian Cancer Progression

    • Lydia W.T. Cheung, Carman K.M. Ip, Alice S.T. Wong

    Pages 225-253

14. PTP4A3, a Signal Molecule Deregulated in Uveal Melanoma Metastasis

    • Cécile Laurent, Jérôme Couturier, Xavier Sastre-Garau, Laurence Desjardins, Emmanuel Barillot, Sophie Piperno-Neumann et al.

    Pages 255-263

15. Signal Transduction Pathways Involved in Hepatocarcinogenesis and Metastasis of Hepatoma

    • Rajagopal N. Aravalli

    Pages 265-282

16. Back Matter

    Pages 283-285

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The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blokcade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study.

• Activation
• Cancer metastasis
• Endoplasmatisches Reticulum
• Integrin
• Migration
• Ras-ERK1/2 MAP signal cascade
• Receptor tyrosine kinase
• molecular mechanisms
• proteins
• signal transduction
• tissue
• Receptors

• Tzu-Chi University, College of Medicine, Institute of medical biotechnology, Hualien, Taiwan R.O.C.

  Wen-Sheng Wu

• Buddhist Tzu-Chi General Hospital, Department of Medicine, Research Center for Hepatology, Hualien, Taiwan R.O.C.

  Chi-Tan Hu

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